INT278962

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.33
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) extracellular space (LEP) small molecule metabolic process (CPOX)
oxidoreductase activity (CPOX) extracellular region (LEP) cytoplasm (CPOX)
Anatomy Link Frequency
cartilage 1
LEP (Homo sapiens)
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 63 98.28 Very High Very High Very High
Pain 2 97.36 Very High Very High Very High
cINOD 3 94.00 High High
cytokine 5 86.44 High High
IPN 1 77.48 Quite High
Inflammation 8 75.76 Quite High
metalloproteinase 3 22.88 Low Low
Kinase C 6 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Kinase C inhibitor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 66 98.28 Very High Very High Very High
Pain 2 97.36 Very High Very High Very High
INFLAMMATION 9 93.08 High High
Adenocarcinoma 1 82.08 Quite High
Inflammatory Pain 1 77.48 Quite High
Glioma 1 52.96 Quite High
Obesity 15 52.52 Quite High
Necrosis 1 48.52 Quite Low
Cancer 1 48.16 Quite Low
Osteophyte 2 38.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge, we show here for the first time that leptin increases COX-2 expression and PGE2 production in human OA cartilage in the absence and in the presence of IL-1 (Figures 1(c), 1(d) and 2(c), 2(d)).
leptin Positive_regulation (increases) of COX in cartilage associated with osteoarthritis
1) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 1.33 Pain Relevance 1.00

General Comments

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