INT278965

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.12
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (NOS2) cytoplasm (NOS2) lipid metabolic process (LEP)
cytosol (NOS2) extracellular space (LEP) extracellular region (LEP)
Anatomy Link Frequency
cartilage 2
LEP (Homo sapiens)
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 117 99.60 Very High Very High Very High
Inflammatory mediators 2 98.00 Very High Very High Very High
Inflammation 14 95.60 Very High Very High Very High
Arthritis 1 94.92 High High
cytokine 6 61.20 Quite High
metalloproteinase 6 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 120 99.60 Very High Very High Very High
INFLAMMATION 16 97.60 Very High Very High Very High
Arthritis 2 94.92 High High
Obesity 119 88.16 High High
Body Weight 2 21.92 Low Low
Overweight 13 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Chronic Disease 2 5.00 Very Low Very Low Very Low
Weight Loss 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although Vuolteenaho and colleagues showed that leptin enhanced the expression of iNOS in human OA cartilage [13], iNOS mRNA level remained unchanged in leptin-treated cells.
leptin Positive_regulation (enhanced) of Gene_expression (expression) of iNOS in cartilage associated with osteoarthritis
1) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.32 Pain Relevance 0.39
Leptin alone or in combination with IL-1 enhanced the expression of iNOS and COX-2, and production of NO, PGE2, IL-6, and IL-8.
Leptin Positive_regulation (enhanced) of Gene_expression (expression) of iNOS
2) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2726438 Disease Relevance 0.80 Pain Relevance 0.28

General Comments

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