INT278965

Context Info Confidence 0.29 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 2.12 Pain Relevance 0.66

intracellular (NOS2) cytoplasm (NOS2) lipid metabolic process (LEP) cytosol (NOS2) extracellular space (LEP) extracellular region (LEP)

Anatomy Link Frequency cartilage 2 LEP (Homo sapiens) NOS2 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 117 99.60 Inflammatory mediators 2 98.00 Inflammation 14 95.60 Arthritis 1 94.92 cytokine 6 61.20 metalloproteinase 6 5.00 Kinase C 6 5.00 cINOD 3 5.00 Pain 3 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 120 99.60 INFLAMMATION 16 97.60 Arthritis 2 94.92 Obesity 119 88.16 Body Weight 2 21.92 Overweight 13 5.00 Pain 3 5.00 Osteophyte 2 5.00 Chronic Disease 2 5.00 Weight Loss 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although Vuolteenaho and colleagues showed that leptin enhanced the expression of iNOS in human OA cartilage [13], iNOS mRNA level remained unchanged in leptin-treated cells.

leptin Positive_regulation (enhanced) of Gene_expression (expression) of iNOS in cartilage associated with osteoarthritis

1) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.32 Pain Relevance 0.39

Leptin alone or in combination with IL-1 enhanced the expression of iNOS and COX-2, and production of NO, PGE2, IL-6, and IL-8.

Leptin Positive_regulation (enhanced) of Gene_expression (expression) of iNOS

2) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2726438 Disease Relevance 0.80 Pain Relevance 0.28

General Comments

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