INT278968

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP, IL6) extracellular region (LEP, IL6) aging (IL6)
lipid metabolic process (LEP)
Anatomy Link Frequency
cartilage 4
LEP (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 126 98.60 Very High Very High Very High
Kinase C 12 96.08 Very High Very High Very High
Inflammation 16 80.04 Quite High
cytokine 10 8.84 Low Low
cINOD 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Kinase C inhibitor 2 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 132 98.60 Very High Very High Very High
INFLAMMATION 18 80.04 Quite High
Obesity 30 77.04 Quite High
Osteophyte 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of NO production reduced the effects of leptin on PGE2, IL-6, and IL-8 production pointing to a mediator role of NO in these leptin-induced changes in cartilage metabolism and to a possible beneficial effect of iNOS inhibitors on OA cartilage.
leptin Spec (possible) Regulation (effects) of Gene_expression (production) of IL-6 in cartilage associated with osteoarthritis
1) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.61 Pain Relevance 0.32
In the present study, inhibition of leptin-induced endogenous NO production in OA cartilage with a selective iNOS inhibitor 1400 W also suppressed the effects of leptin on PGE2, IL-6, and IL-8 production.
leptin Regulation (effects) of Gene_expression (production) of IL-6 in cartilage associated with osteoarthritis
2) Confidence 0.29 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.50 Pain Relevance 0.37

General Comments

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