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Context Info
Confidence 0.52
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.03
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK3) cytoskeleton (JAK3) cytoplasm (JAK3)
Anatomy Link Frequency
B lymphocytes 1
JAK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 99.52 Very High Very High Very High
Osteoarthritis 63 92.08 High High
tolerance 3 90.96 High High
rheumatoid arthritis 52 78.88 Quite High
antagonist 3 78.24 Quite High
anakinra 1 77.36 Quite High
corticosteroid 41 77.28 Quite High
Inflammation 22 75.92 Quite High
Bioavailability 6 66.00 Quite High
abatacept 2 63.76 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 66 92.08 High High
Anaemia 5 79.44 Quite High
Rheumatoid Arthritis 52 78.88 Quite High
INFLAMMATION 25 75.92 Quite High
Severe Combined Immunodeficiency 1 57.12 Quite High
Neointima 1 56.12 Quite High
Cytomegalovirus Infection 8 51.64 Quite High
Disease 31 50.56 Quite High
Necrosis 3 22.72 Low Low
Cancer 6 22.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of signaling pathways (JNK, p38, and Erk1/2 MAP-kinases, JAK2 and JAK3, PKC, and transcription factor NF-?
Gene_expression (kinases) of JAK3
1) Confidence 0.52 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.39 Pain Relevance 0.23
JAK-1 and JAK-2 are activated by a broad range of cytokines that use gp130 whereas JAK-3 which is highly expressed in lymphoid cells is activated only by cytokines that bind to gamma-chain-containing receptors.
Gene_expression (expressed) of JAK-3 associated with cytokine
2) Confidence 0.27 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.24 Pain Relevance 0.30
Some that are currently in development and at the trial stages are agents targeting IL-1, cytokines from the TNF superfamily, IL-15, IL-17, B lymphocytes, IL-12/IL-23, SyK kinase, JAK3 kinase, and inhibitors of osteoclastogenesis.40–51

Chemistry and mechanism of action

Gene_expression (/) of JAK3 kinase in B lymphocytes associated with cytokine
3) Confidence 0.05 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.40 Pain Relevance 0.44

General Comments

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