INT278979

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
fat 2
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 63 96.32 Very High Very High Very High
medulla 4 20.88 Low Low
antagonist 20 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
agonist 17 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Somatostatin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 100.00 Very High Very High Very High
Osteoarthritis 66 96.32 Very High Very High Very High
Hypertrophy 2 92.88 High High
Renal Failure 4 81.64 Quite High
Cancer 7 69.80 Quite High
Body Weight 4 67.04 Quite High
Carcinoma 3 59.64 Quite High
Reprotox - General 1 1 27.76 Quite Low
Apoptosis 9 25.60 Quite Low
Obesity 30 24.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
g/mL) IL-6, IL-8, and PGE2 production was studied by inhibiting leptin-induced endogenous NO production with a selective iNOS inhibitor 1400 W (1 mM) during a 48 hour incubation of OA explants from 8 patients.
Negative_regulation (inhibiting) of Neg (NO) Positive_regulation (endogenous) of leptin-induced associated with osteoarthritis
1) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.28 Pain Relevance 0.14
Relevant mechanisms embrace repression of insulin-sensitizing genes, such as adiponectin, and induction of adipocyte leptin and peroxisome-proliferating activator receptor- (PPAR-) gamma genes; stimulation of endothelial lipoprotein lipase, adipocyte fatty acid synthase, acetyl CoA carboxylase, and fat-cell glucose uptake; and inhibition of fat oxidation via rate-limiting carnitine-palmitoyl transferase [167, 171, 172, 191, 554, 555].
Negative_regulation (repression) of Positive_regulation (induction) of adipocyte leptin in fat associated with repression
2) Confidence 0.08 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.52 Pain Relevance 0

General Comments

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