INT278981

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.12
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK3) cytoskeleton (JAK3) cytoplasm (JAK3)
JAK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 26 99.92 Very High Very High Very High
Osteoarthritis 252 97.64 Very High Very High Very High
Inflammation 52 97.00 Very High Very High Very High
cytokine 58 96.56 Very High Very High Very High
corticosteroid 74 47.00 Quite Low
Bioavailability 12 35.72 Quite Low
Pain 8 13.92 Low Low
cINOD 12 10.56 Low Low
agonist 4 8.08 Low Low
Leflunomide 2 6.36 Low Low
Disease Link Frequency Relevance Heat
Thrombocytopenia 8 99.12 Very High Very High Very High
Renal Failure 22 98.24 Very High Very High Very High
Anaemia 8 97.76 Very High Very High Very High
Osteoarthritis 264 97.64 Very High Very High Very High
INFLAMMATION 56 97.00 Very High Very High Very High
Severe Combined Immunodeficiency 2 93.68 High High
Adenocarcinoma 4 26.88 Quite Low
Neointima 2 25.84 Quite Low
Obesity 60 24.84 Low Low
Cytomegalovirus Infection 16 21.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied the effects of inhibitors of JAK (JAK2 and JAK3), MAPK (Erk1/2, p38, JNK), PKC and NF-?
Negative_regulation (inhibitors) of JAK associated with kinase c
1) Confidence 0.46 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.35 Pain Relevance 0.37
We studied the effects of inhibitors of JAK (JAK2 and JAK3), MAPK (Erk1/2, p38, JNK), PKC and NF-?
Negative_regulation (inhibitors) of JAK3 associated with kinase c
2) Confidence 0.33 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.36 Pain Relevance 0.37
Leptin-induced NO production was suppressed by inhibitors of JNK, JAK3, PKC, and NF-?
Negative_regulation (inhibitors) of JAK3 associated with kinase c
3) Confidence 0.33 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.41 Pain Relevance 0.41
M (JAK3 inhibitor), Ro 31-8220 1 ?
Negative_regulation (inhibitor) of JAK3
4) Confidence 0.33 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.29 Pain Relevance 0.15
However, several concerns exist with JAK3 inhibition.
Negative_regulation (inhibition) of JAK3
5) Confidence 0.20 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.33 Pain Relevance 0.22
CP-690,550, a JAK3 inhibitor, is currently undergoing phase 2 trials in renal transplant recipients versus tacrolimus with all patients also being maintained on MMF and steroids.
Negative_regulation (inhibitor) of JAK3 associated with renal failure
6) Confidence 0.20 Published 2009 Journal Journal of Transplantation Section Body Doc Link PMC2809333 Disease Relevance 0.38 Pain Relevance 0.17

General Comments

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