INT278982

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.97
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPHB2)
Anatomy Link Frequency
amygdala 1
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 2 99.32 Very High Very High Very High
Osteoarthritis 63 93.96 High High
Kinase C 36 85.84 High High
cytokine 28 84.76 Quite High
Central nervous system 24 79.60 Quite High
long-term potentiation 2 39.20 Quite Low
Neuropathic pain 4 30.48 Quite Low
Migraine 4 29.64 Quite Low
Kinase C inhibitor 1 27.12 Quite Low
Hippocampus 9 20.88 Low Low
Disease Link Frequency Relevance Heat
Cancer 52 97.68 Very High Very High Very High
Osteoarthritis 66 93.96 High High
Drug Induced Neurotoxicity 3 88.56 High High
Targeted Disruption 10 88.00 High High
Necrosis 3 83.40 Quite High
Glioma 29 80.76 Quite High
Syndrome 5 79.28 Quite High
Down Syndrome 1 79.12 Quite High
Cognitive Disorder 9 77.92 Quite High
Disease 69 75.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of signaling pathways (JNK, p38, and Erk1/2 MAP-kinases, JAK2 and JAK3, PKC, and transcription factor NF-?
Regulation (involvement) of Erk1
1) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.39 Pain Relevance 0.24
In addition, a role for mitogen-activated protein kinases (MAPK) (i.e., extracellular signal-regulated kinase, ERK1/2 and p38), and phosphatidylinositol-3 kinase (Pi3K) in IL-18 signalling has been suggested [4,44-46].
Regulation (regulated) of ERK1
2) Confidence 0.44 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 0.24 Pain Relevance 0.04
Erk1/2 are known to regulate cell motility [20].
Regulation (regulate) of Erk1
3) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
can also impair amygdala-dependent emotional responses by affecting the ERK/MAPK signaling pathway [153].
Regulation (affecting) of ERK in amygdala associated with amygdala
4) Confidence 0.44 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.56 Pain Relevance 0.05
The aim of the present study was to investigate the relationships between VPA-induced changes in HDAC and Erk1/2 activities, and cell growth and motility.
Spec (investigate) Regulation (changes) of Erk1
5) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.19 Pain Relevance 0.03
However, these effects may also be partially caused by alterations in, for example, Erk1/2 activity.
Regulation (alterations) of Erk1
6) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.15 Pain Relevance 0.10
These results suggest that the cell type-specific effects of VPA on the activity of Erk1/2 are important in relation to the use of VPA as an anti-cancer drug.


Regulation (effects) of Erk1 associated with cancer
7) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.44 Pain Relevance 0.07

General Comments

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