INT279017

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.69
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Sirpa) cytoskeleton organization (Sirpa)
Anatomy Link Frequency
microglia 2
Sirpa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 108 98.16 Very High Very High Very High
Inflammation 6 96.44 Very High Very High Very High
Peripheral nerve injury 12 50.00 Quite Low
Neuropathic pain 15 5.00 Very Low Very Low Very Low
Lasting pain 6 5.00 Very Low Very Low Very Low
analgesia 6 5.00 Very Low Very Low Very Low
Dorsal horn 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 96.44 Very High Very High Very High
Necrosis 3 95.96 Very High Very High Very High
Cancer 3 95.60 Very High Very High Very High
Injury 15 95.36 Very High Very High Very High
Nervous System Injury 48 70.04 Quite High
Viral Meningitis 3 59.84 Quite High
Disease 3 10.76 Low Low
Stress Incontinence 21 5.00 Very Low Very Low Very Low
Neuropathic Pain 18 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detection of CD172a upregulation on contralateral regions, albeit smaller than ipsilateral values at equivalent time points, suggest that CD172a expression may be a sensitive indicator of both regional and non-regional microglia activation status.
Positive_regulation (upregulation) of CD172a in microglia
1) Confidence 0.16 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.18 Pain Relevance 0.14
The upregulation of microglia surface CD172a observed in the L5 SNT model could therefore represent a homeostatic response, limiting inflammation and potential injury.
Positive_regulation (upregulation) of CD172a in microglia associated with inflammation and injury
2) Confidence 0.14 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.44 Pain Relevance 0.08
Detection of CD172a upregulation on contralateral regions, albeit smaller than ipsilateral values at equivalent time points, suggest that CD172a expression could be a more sensitive indicator of (regional and non-regional) early microgliosis using flow cytometric analyses than quantification of the total size of the microglial population.


Positive_regulation (upregulation) of CD172a
3) Confidence 0.11 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

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