INT279107

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.43
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COMP, MATN3) proteinaceous extracellular matrix (COMP, MATN3) extracellular space (COMP)
cell adhesion (COMP)
Anatomy Link Frequency
cartilage 2
COMP (Homo sapiens)
MATN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 9 66.16 Quite High
Pain 6 63.32 Quite High
Disease Link Frequency Relevance Heat
Osteochondrodysplasias 132 100.00 Very High Very High Very High
Disease 54 98.82 Very High Very High Very High
Osteoarthritis 12 66.16 Quite High
Pain 6 63.32 Quite High
Cleidocranial Dysplasia 12 60.80 Quite High
Syndrome 3 46.36 Quite Low
Muscle Disease 3 33.28 Quite Low
Adhesions 6 22.92 Low Low
Bone Cancer 6 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Matrilin-3/1 isolated from cartilage has been shown to bind with high affinity to both COMP and type IX collagen [Briggs and Chapman, 2002; Mann et al., 2004].
COMP Binding (bind) of Matrilin in cartilage
1) Confidence 0.41 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.63 Pain Relevance 0.10
Several missense mutations in MATN3 have been associated with MED, including p.Arg121Trp, p.Val194Asp [Chapman et al., 2001], p.Thr120Met, p.Glu134Lys, p.Ile192Asn, and p.Ala219Asp [Jackson et al., 2004].
MED Binding (associated) of MATN3 associated with osteochondrodysplasias
2) Confidence 0.41 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.48 Pain Relevance 0.11
Although our initial studies were focused on understanding the disease mechanism in vitro, the chance to study cartilage from an MED patient with a MATN3 mutation (p.Arg121Trp) provided us with the opportunity to confirm these findings in vivo.
MED Binding (patient) of MATN3 in cartilage associated with osteochondrodysplasias and disease
3) Confidence 0.36 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.33 Pain Relevance 0

General Comments

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