INT279121

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (MCC) plasma membrane (MCC) nucleus (MCC)
cytoplasm (MCC)
Anatomy Link Frequency
chondrocytes 2
MCC (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleidocranial Dysplasia 4 80.72 Quite High
Osteochondrodysplasias 44 77.08 Quite High
Disease 18 76.56 Quite High
Death 1 67.40 Quite High
Osteoarthritis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bone Cancer 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low
Coagulation Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently there has been much speculation about the reason for this genetic heterogeneity, and a number of hypotheses have been suggested; i.e., 1) some mutations disrupt specific interactions between matrilin-3, type IX collagen, and COMP in the cartilage ECM [Briggs and Chapman, 2002]; 2) the blocked/delayed secretion of one mutant protein results in a cascade of protein retention within the rER of chondrocytes [Unger and Hecht, 2001]; or 3) a combination of both mechanisms [Dinser et al., 2002].
Positive_regulation (results) of Localization (secretion) of mutant protein in chondrocytes
1) Confidence 0.01 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.38 Pain Relevance 0

General Comments

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