INT279122

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 8.82
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COMP) extracellular region (COMP) cell adhesion (COMP)
proteinaceous extracellular matrix (COMP)
Anatomy Link Frequency
ligaments 8
tendons 2
synovium 2
COMP (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 37 100.00 Very High Very High Very High
Osteoarthritis 29 100.00 Very High Very High Very High
Arthritis 312 98.04 Very High Very High Very High
Inflammation 48 88.56 High High
imagery 19 81.04 Quite High
psoriasis 114 74.20 Quite High
Pain 20 23.00 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteochondrodysplasias 46 100.00 Very High Very High Very High
Rheumatoid Arthritis 37 100.00 Very High Very High Very High
Osteoarthritis 30 100.00 Very High Very High Very High
Cytomegalovirus Infection 8 99.68 Very High Very High Very High
Bone Cancer 2 99.64 Very High Very High Very High
Rheumatic Diseases 36 99.60 Very High Very High Very High
Disease 97 98.28 Very High Very High Very High
Arthritis 78 98.04 Very High Very High Very High
Congenital Anomalies 27 82.52 Quite High
Seronegative Spondarthritis 246 75.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The bicistronic constructs were designed to express MT- or WT-COMP with a FLAG tag moiety (DYKDDDDK) at the carboxy terminus and GFP reporter gene under the control of the cytomegalovirus (CMV) promoter.
Regulation (control) of Gene_expression (express) of WT-COMP associated with cytomegalovirus infection
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.31 Pain Relevance 0
COMP is a tissue specific pentameric glycoprotein and one component of the extracellular articular cartilage matrix and belongs to the thrombospondin family.11 It was first detected in the serum and synovial fluid of patients suffering from rheumatic disorders such as rheumatoid arthritis and osteoarthritis.12 However much less known about COMP production in synovial cells in other rheumatic diseases.13 Originally it is considered a marker of cartilage breakdown, but it has also been identified in tendons, ligaments and synovium.14 It has potential as a diagnostic and prognostic indicator and as a marker of the rheumatic disease severity and the effect of treatment.12,15
Regulation (synovial cells) of Gene_expression (production) of COMP in ligaments associated with rheumatoid arthritis, osteoarthritis and rheumatic diseases
2) Confidence 0.39 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.45 Pain Relevance 0.60
COMP is a tissue specific pentameric glycoprotein and one component of the extracellular articular cartilage matrix and belongs to the thrombospondin family.11 It was first detected in the serum and synovial fluid of patients suffering from rheumatic disorders such as rheumatoid arthritis and osteoarthritis.12 However much less known about COMP production in synovial cells in other rheumatic diseases.13 Originally it is considered a marker of cartilage breakdown, but it has also been identified in tendons, ligaments and synovium.14 It has potential as a diagnostic and prognostic indicator and as a marker of the rheumatic disease severity and the effect of treatment.12,15
Regulation (synovial cells) of Gene_expression (production) of COMP in ligaments associated with rheumatoid arthritis, osteoarthritis and rheumatic diseases
3) Confidence 0.39 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.11 Pain Relevance 0.46
Most of the MED mutations in MATN3 affect conserved residues in one of the six ?
Regulation (Most) of Gene_expression (mutations) of MED associated with osteochondrodysplasias
4) Confidence 0.38 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.83 Pain Relevance 0
COMP is a tissue specific pentameric glycoprotein and one component of the extracellular articular cartilage matrix and belongs to the thrombospondin family.11 It was first detected in the serum and synovial fluid of patients suffering from rheumatic disorders such as rheumatoid arthritis and osteoarthritis.12 However much less known about COMP production in synovial cells in other rheumatic diseases.13 Originally it is considered a marker of cartilage breakdown, but it has also been identified in tendons, ligaments and synovium.14 It has potential as a diagnostic and prognostic indicator and as a marker of the rheumatic disease severity and the effect of treatment.12,15
Regulation (synovial cells) of in synovium Gene_expression (production) of COMP in ligaments associated with rheumatoid arthritis, osteoarthritis and rheumatic diseases
5) Confidence 0.13 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.11 Pain Relevance 0.46
COMP is a tissue specific pentameric glycoprotein and one component of the extracellular articular cartilage matrix and belongs to the thrombospondin family.11 It was first detected in the serum and synovial fluid of patients suffering from rheumatic disorders such as rheumatoid arthritis and osteoarthritis.12 However much less known about COMP production in synovial cells in other rheumatic diseases.13 Originally it is considered a marker of cartilage breakdown, but it has also been identified in tendons, ligaments and synovium.14 It has potential as a diagnostic and prognostic indicator and as a marker of the rheumatic disease severity and the effect of treatment.12,15
Regulation (synovial cells) of in tendons Gene_expression (production) of COMP in ligaments associated with rheumatoid arthritis, osteoarthritis and rheumatic diseases
6) Confidence 0.13 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.45 Pain Relevance 0.60
COMP is a tissue specific pentameric glycoprotein and one component of the extracellular articular cartilage matrix and belongs to the thrombospondin family.11 It was first detected in the serum and synovial fluid of patients suffering from rheumatic disorders such as rheumatoid arthritis and osteoarthritis.12 However much less known about COMP production in synovial cells in other rheumatic diseases.13 Originally it is considered a marker of cartilage breakdown, but it has also been identified in tendons, ligaments and synovium.14 It has potential as a diagnostic and prognostic indicator and as a marker of the rheumatic disease severity and the effect of treatment.12,15
Regulation (synovial cells) of in synovium Gene_expression (production) of COMP in ligaments associated with rheumatoid arthritis, osteoarthritis and rheumatic diseases
7) Confidence 0.13 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.45 Pain Relevance 0.60
COMP is a tissue specific pentameric glycoprotein and one component of the extracellular articular cartilage matrix and belongs to the thrombospondin family.11 It was first detected in the serum and synovial fluid of patients suffering from rheumatic disorders such as rheumatoid arthritis and osteoarthritis.12 However much less known about COMP production in synovial cells in other rheumatic diseases.13 Originally it is considered a marker of cartilage breakdown, but it has also been identified in tendons, ligaments and synovium.14 It has potential as a diagnostic and prognostic indicator and as a marker of the rheumatic disease severity and the effect of treatment.12,15
Regulation (synovial cells) of in tendons Gene_expression (production) of COMP in ligaments associated with rheumatoid arthritis, osteoarthritis and rheumatic diseases
8) Confidence 0.13 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.11 Pain Relevance 0.46

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