INT279128

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MATN3) proteinaceous extracellular matrix (MATN3)
MATN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Lasting pain 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chondrosarcoma 12 99.34 Very High Very High Very High
Osteochondrodysplasias 46 95.68 Very High Very High Very High
Targeted Disruption 8 89.96 High High
Disease 19 71.60 Quite High
Stress 13 71.44 Quite High
Metastasis 1 30.88 Quite Low
Lysosome Storage Disease 1 21.40 Low Low
Gauchers Disease 1 20.56 Low Low
Cancer 2 17.68 Low Low
Age-related Macular Degeneration 3 12.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data therefore suggested that the p.Val194Asp mutation prevented the proper trafficking and secretion of matrilin-3, whereas as the p.Glu252Lys polymorphism did not.


Negative_regulation (prevented) of Localization (secretion) of matrilin
1) Confidence 0.43 Published 2005 Journal Human Mutation Section Body Doc Link PMC2726956 Disease Relevance 0.58 Pain Relevance 0
We also demonstrated in RCS cells that shRNA 3B efficiently reduced intracellular retention of MT-COMP, MATN3 and type IX collagen, thereby preventing the development of intracellular matrix that defines the PSACH and MED/EDM1 cellular phenotype.
Negative_regulation (reduced) of Localization (retention) of MATN3 associated with chondrosarcoma
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.35 Pain Relevance 0

General Comments

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