INT279130

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.75
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COMP) extracellular region (COMP) cell adhesion (COMP)
proteinaceous extracellular matrix (COMP)
Anatomy Link Frequency
chondrocytes 2
joints 2
COMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 52 96.92 Very High Very High Very High
psoriasis 19 95.96 Very High Very High Very High
Pain 5 95.16 Very High Very High Very High
cytokine 1 92.24 High High
Osteoarthritis 13 92.12 High High
imagery 6 55.56 Quite High
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteochondrodysplasias 50 100.00 Very High Very High Very High
Stress 39 99.58 Very High Very High Very High
Chondrosarcoma 36 99.34 Very High Very High Very High
Cleidocranial Dysplasia 7 98.64 Very High Very High Very High
Seronegative Spondarthritis 41 96.92 Very High Very High Very High
Rheumatic Diseases 6 96.12 Very High Very High Very High
Psoriasis 30 95.96 Very High Very High Very High
Growth Problems 4 95.88 Very High Very High Very High
Pain 7 95.16 Very High Very High Very High
Necrosis 1 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
shRNA 3B is effective in reducing intracellular retention of MT-COMP and other ECM proteins
Negative_regulation (reducing) of Localization (retention) of MT-COMP
1) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.18 Pain Relevance 0
They stimulate chondrocytes to release destructive proteases which lead to loss of proteoglycans, to destruction of collagen bundles and to the release of COMP.13 Despite the presence of previous studies on the utility of ultrasound and serum COMP in many rheumatic diseases, their combined validity, sensitivity and specificity in patients with psoriasis and psoriatic arthritis has not been previously reported.
Negative_regulation (loss) of Localization (release) of COMP in chondrocytes associated with seronegative spondarthritis, psoriasis, rheumatic diseases and arthritis
2) Confidence 0.38 Published 2010 Journal Clin Med Insights Arthritis Musculoskelet Disord Section Body Doc Link PMC2989640 Disease Relevance 1.59 Pain Relevance 0.55
Alternatively, increased ER stress (CRT levels) and co-localization of CRT and COMP were greatly diminished in cells overexpressing MT-COMP in the presence of shRNA 3B (Fig. 3I–L).
Negative_regulation (diminished) of Localization (localization) of COMP associated with stress
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.72 Pain Relevance 0
We also demonstrated in RCS cells that shRNA 3B efficiently reduced intracellular retention of MT-COMP, MATN3 and type IX collagen, thereby preventing the development of intracellular matrix that defines the PSACH and MED/EDM1 cellular phenotype.
Negative_regulation (reduced) of Localization (retention) of MT-COMP associated with chondrosarcoma
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858657 Disease Relevance 0.35 Pain Relevance 0
Multiple epiphyseal dysplasia mutations in MATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3

Multiple epiphyseal dysplasia (MED) is a relatively common skeletal dysplasia that can present in childhood with a variable phenotype of short stature and pain and stiffness in the large joints, and often progresses to early-onset osteoarthritis in adulthood.

Negative_regulation (prevent) of Localization (secretion) of MED in joints associated with pain, osteochondrodysplasias, cleidocranial dysplasia, osteoarthritis and growth problems
5) Confidence 0.36 Published 2005 Journal Human Mutation Section Title Doc Link PMC2726956 Disease Relevance 0.91 Pain Relevance 0.14

General Comments

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