INT279145

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (VHL, RNF139) mitochondrion (VHL) cell morphogenesis (VHL)
extracellular matrix organization (VHL) ligase activity (RNF139) response to stress (VHL)
VHL (Homo sapiens)
RNF139 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 4 99.04 Very High Very High Very High
Hypoxia 8 98.64 Very High Very High Very High
Cancer 64 98.24 Very High Very High Very High
Renal Cancer 16 93.60 High High
Glioblastoma 2 89.84 High High
Basal Cell Carcinoma 4 89.12 High High
Dysgerminoma 58 88.72 High High
Congenital Anomalies 2 74.56 Quite High
Medulloblastoma 2 56.64 Quite High
Germ Cell And Embryonal Neoplasms 2 30.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRC8 interacts with VHL and, in fruit flies, knockdown of either gene led to a similar embryonic phenotype [12].
VHL Binding (interacts) of TRC8
1) Confidence 0.30 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.85 Pain Relevance 0
Haploinsufficiency of TRC8 may facilitate development of clear cell-RCC in association with VHL mutations, and may increase risk for other tumor types.
VHL Spec (clear) Binding (association) of TRC8 associated with cancer
2) Confidence 0.20 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2727492 Disease Relevance 1.02 Pain Relevance 0

General Comments

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