INT279156

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Context Info
Confidence 0.64
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 5.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (TSN) nucleus (TSN) DNA binding (TSN)
cytoplasm (TSN)
Anatomy Link Frequency
ovary 3
testis 1
TSN (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 7 5.00 Very Low Very Low Very Low
abdominal pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysgerminoma 203 99.92 Very High Very High Very High
Congenital Anomalies 7 99.40 Very High Very High Very High
Cancer 224 97.96 Very High Very High Very High
Aneuploidy 7 88.80 High High
Epstein-barr Virus 42 85.68 High High
Thyroid Neoplasm 14 82.28 Quite High
Genetic Translocation 14 80.16 Quite High
Glioblastoma 7 73.08 Quite High
Basal Cell Carcinoma 14 72.36 Quite High
Renal Cancer 56 60.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our patient Translin (TSN), a protein involved in post-transcriptional regulation of TRC8 and of a number of genes during spermatogenesis, is expressed two times less in the dysgerminoma than in normal ovary.
Gene_expression (expressed) of TSN in ovary associated with dysgerminoma
1) Confidence 0.64 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.57 Pain Relevance 0
We quantified expression of the TSN gene encoding translin, a protein involved in post-transcriptional regulation of a number of genes, including TRC8, during spermatogenesis (Fig. 7B).
Gene_expression (expression) of TSN
2) Confidence 0.64 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.71 Pain Relevance 0
In our patient Translin (TSN), a protein involved in post-transcriptional regulation of TRC8 and of a number of genes during spermatogenesis, is expressed two times less in the dysgerminoma than in normal ovary.
Gene_expression (expressed) of Translin in ovary associated with dysgerminoma
3) Confidence 0.64 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.57 Pain Relevance 0
We quantified expression of the TSN gene encoding translin, a protein involved in post-transcriptional regulation of a number of genes, including TRC8, during spermatogenesis (Fig. 7B).
Gene_expression (expression) of translin
4) Confidence 0.56 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.72 Pain Relevance 0
Expression of genes TRC8 and TSN was tested both on dysgerminoma and in the proposita and her father.


Gene_expression (Expression) of TSN associated with dysgerminoma
5) Confidence 0.50 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2727492 Disease Relevance 1.19 Pain Relevance 0
Translin is underexpressed in the dysgerminoma compared to normal ovary.
Gene_expression (underexpressed) of Translin in ovary associated with dysgerminoma
6) Confidence 0.50 Published 2009 Journal Mol Cancer Section Abstract Doc Link PMC2727492 Disease Relevance 1.06 Pain Relevance 0
TSN was expressed approximately 3 times more in the testis than in normal ovary, while it was expressed approximately two times less in the dysgerminoma.
Gene_expression (expressed) of TSN in testis associated with dysgerminoma
7) Confidence 0.43 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.85 Pain Relevance 0

General Comments

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