INT27916

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 14
Disease Relevance 4.40
Pain Relevance 7.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mt1a) nucleus (Mt1a) intracellular (Mt1a)
lysosome (Mt1a) cytoplasm (Mt1a)
Anatomy Link Frequency
MT2 2
midline 1
T cells 1
Mt1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 648 100.00 Very High Very High Very High
lidocaine 333 100.00 Very High Very High Very High
Central nervous system 11 99.48 Very High Very High Very High
Somatosensory cortex 9 98.88 Very High Very High Very High
Anterior cingulate cortex 801 96.28 Very High Very High Very High
withdrawal 9 94.44 High High
Pain 172 93.28 High High
antidepressant 36 80.40 Quite High
antagonist 6 76.88 Quite High
agonist 8 73.80 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 70 100.00 Very High Very High Very High
Nociception 279 98.96 Very High Very High Very High
Cancer 153 98.00 Very High Very High Very High
Metastasis 52 97.40 Very High Very High Very High
Pain 172 93.28 High High
Pancreatic Cancer 1 89.76 High High
Chronic Renal Failure 1 86.56 High High
Malignant Neoplastic Disease 11 84.20 Quite High
Shock 54 78.52 Quite High
Lymphatic System Cancer 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
5 M) for all potential targets except: MT1 (KI = 0.1 nM); MT2 (KI = 0.12 nM) (Audinot et al 2003); and 5HT2C (pKi = 6.2 ?
Gene_expression (5HT2C) of MT1 in MT2
1) Confidence 0.47 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655086 Disease Relevance 0 Pain Relevance 0.37
5 M) for all potential targets except: MT1 (KI = 0.1 nM); MT2 (KI = 0.12 nM) (Audinot et al 2003); and 5HT2C (pKi = 6.2 ?
Gene_expression (targets) of MT1 in MT2
2) Confidence 0.47 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2655086 Disease Relevance 0 Pain Relevance 0.36
The same procedure was applied to the MT lesion (n = 12) and MT Sham (n = 5) groups.
Gene_expression (lesion) of MT associated with thalamus
3) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.07 Pain Relevance 0.44
Reversible lesions of the MT immediately after behavioral training, but not before behavioral testing, disrupted the retention of the 24 h inhibitory avoidance.
Gene_expression (lesions) of MT associated with thalamus
4) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.65 Pain Relevance 0.80
Effects of microinfusions of lidocaine into the MT
Gene_expression (Effects) of MT associated with thalamus and lidocaine
5) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.27 Pain Relevance 0.90
The lesions of the MT are shown in Fig. 3a.
Gene_expression (lesions) of MT associated with thalamus
6) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.05 Pain Relevance 0.89
Effects of MT lesions
Gene_expression (lesions) of MT associated with thalamus
7) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0 Pain Relevance 0.96
If the MT is damaged, then no further processing of nociceptive information would occur.
Gene_expression (damaged) of MT associated with nociception and thalamus
8) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.56 Pain Relevance 0.69
Effects of MT lesions
Gene_expression (lesions) of MT associated with thalamus
9) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.55 Pain Relevance 0.82
The same procedure was applied to the MT lesion (n = 12) and MT Sham (n = 5) groups.
Gene_expression (lesion) of MT associated with thalamus
10) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.07 Pain Relevance 0.44
For lesions of the MT, two holes were drilled 2.5 mm posterior to bregma and 0.5 mm lateral to the midline bilaterally.
Gene_expression (lesions) of MT in midline associated with thalamus
11) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0 Pain Relevance 0.30
Human MT-1 cells stably transfected with the G3 construct or the control vector were cultured at a density of 1 × 105 cells/ml/well on 12-well tissue culture plates in RPMI-1640 media (Life Technologies, Inc.
Gene_expression (transfected) of MT-1
12) Confidence 0.04 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.14 Pain Relevance 0
Athymic rats injected with versican G3 transfected human breast carcinoma cells (MT-1) were observed to demonstrate a greater systemic tumor burden than animals injected with control cells.
Gene_expression (transfected) of MT-1 associated with cancer and breast cancer
13) Confidence 0.04 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.49 Pain Relevance 0
An immunohistochemical study showed that the LCA, MB-1, and the LN-1 for B cell markers were positive, while the MT-1 for T cells was negative.
Neg (negative) Gene_expression (negative) of MT-1 in T cells
14) Confidence 0.02 Published 1989 Journal Gan No Rinsho Section Abstract Doc Link 2691718 Disease Relevance 0.56 Pain Relevance 0.07

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