INT279178

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 19 98.66 Very High Very High Very High
Genomic Instability 2 86.44 High High
Renal Cancer 43 76.12 Quite High
Von Hippel-lindau Syndrome 9 67.72 Quite High
Apoptosis 1 62.96 Quite High
Malignant Neoplastic Disease 1 59.68 Quite High
Syndrome 5 51.28 Quite High
Hypoxia 2 34.40 Quite Low
Immunotherapy Of Cancer 1 9.16 Low Low
Toxicity 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Drugs may also act indirectly by antibody binding of elevated levels of extracellular angiogenic growth factors eg, bevacizumab (Avastin®, Genentech), acting on overexpressed receptors on tumor cells themselves eg, sunitinib, sorafenib (Nexavar®, Bayer) or by inhibiting related pathways such as mTOR upregulation of VEGF and HIF1?
Negative_regulation (inhibiting) of Positive_regulation (upregulation) of mTOR associated with cancer
1) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727778 Disease Relevance 0.80 Pain Relevance 0

General Comments

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