INT27918

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Context Info
Confidence 0.36
First Reported 1986
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.89
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Klk1c7)
Anatomy Link Frequency
articular 1
adrenal medulla 1
Klk1c7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 21 100.00 Very High Very High Very High
bradykinin 12 100.00 Very High Very High Very High
medulla 4 100.00 Very High Very High Very High
5HT 10 99.92 Very High Very High Very High
Inflammation 63 99.28 Very High Very High Very High
Pain 78 98.16 Very High Very High Very High
analgesia 7 97.72 Very High Very High Very High
mu opioid receptor 1 96.48 Very High Very High Very High
Neurotransmitter 4 95.96 Very High Very High Very High
cerebral cortex 2 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 2 99.52 Very High Very High Very High
INFLAMMATION 81 99.28 Very High Very High Very High
Injury 15 98.88 Very High Very High Very High
Arthropathy 1 98.76 Very High Very High Very High
Pain 57 98.16 Very High Very High Very High
Cardiovascular Disease 12 98.12 Very High Very High Very High
Periodontal Disease 48 95.00 High High
Myocardial Infarction 7 93.44 High High
Rheumatoid Arthritis 3 91.64 High High
Wound Healing 7 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proteinase inhibitors do not potentiate the response to 5HT, suggesting that 5HT's effect is not due to stimulation of release of a peptide neurotransmitter.
Neg (not) Positive_regulation (potentiate) of Proteinase associated with neurotransmitter and 5ht
1) Confidence 0.36 Published 1986 Journal Life Sci. Section Abstract Doc Link 3003490 Disease Relevance 0 Pain Relevance 0.79
These results suggested that 1) BK was an activator for BANA-degrading enzymes which were thought as processing proteinases of ME-like peptides in adrenal medulla of the rat, and 2) there may be, at least, two kinds of BANA-degrading enzymes activated by BK, one might be a serine proteinase with optimal pH at 6, and the others might be cysteine proteinases with optimal pH at both 6 and 8.
Positive_regulation (activator) of proteinase in adrenal medulla associated with medulla and bradykinin
2) Confidence 0.27 Published 1989 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 2692419 Disease Relevance 0 Pain Relevance 0.70
The following study corroborates these findings and identifies the major proteinase responsible for insulin degradation in wound fluid (WF).
Positive_regulation (responsible) of proteinase associated with injury
3) Confidence 0.06 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9357792 Disease Relevance 0.43 Pain Relevance 0.16
Proteinase levels are known to be augmented in patients with inflammatory joint disease [125-128], and it is believed that their enzymatic destruction of cartilage and other intra-articular tissues is a major contributing factor to the pathogenesis of rheumatoid arthritis.
Positive_regulation (augmented) of Proteinase in articular associated with inflammation, rheumatoid arthritis and arthropathy
4) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794504 Disease Relevance 1.05 Pain Relevance 0.72
Its structure appears to satisfy the substrate requirements of the proteinase, dipeptidyl peptidase IV which removes dipeptides from the amino terminus of peptides containing proline as the penultimate amino acid.
Positive_regulation (requirements) of proteinase
5) Confidence 0.01 Published 1999 Journal Brain Res. Section Abstract Doc Link 9878785 Disease Relevance 0 Pain Relevance 0.36
Myocardial ischaemia is associated with the activation of MMPs and the serine proteinase plasmin.
Positive_regulation (activation) of proteinase associated with coronary artery disease and metalloproteinase
6) Confidence 0.01 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 1.40 Pain Relevance 0.11

General Comments

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