INT279195

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.52
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SYCP3) cell cycle (SYCP3) DNA binding (SYCP3)
cell division (SYCP3)
Anatomy Link Frequency
neuronal 1
SYCP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sciatic nerve 6 93.68 High High
isoflurane 2 86.64 High High
Pain 8 71.56 Quite High
chemokine 52 50.00 Quite Low
antagonist 18 38.88 Quite Low
anesthesia 1 34.16 Quite Low
dorsal root ganglion 42 5.80 Low Low
cytokine 16 5.00 Very Low Very Low Very Low
Neuropathic pain 12 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 4 97.36 Very High Very High Very High
Congenital Myasthenic Syndromes 22 96.20 Very High Very High Very High
Pancreatic Cancer 70 93.56 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 21 93.56 High High
Injury 33 90.00 High High
Small Cell Lung Cancer 4 87.76 High High
Malignant Neoplastic Disease 9 73.44 Quite High
Pain 7 71.56 Quite High
Glioma 2 56.68 Quite High
Non-small-cell Lung Cancer 17 56.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to recent findings, NRSF/REST represses the expression of many neuron-specific genes in non-neuronal cells, interacting with histone deacetylases, mSin3, and CoR-EST (Ballas and Mandel, 2005).
CoR Binding (interacting) of in neuronal
1) Confidence 0.47 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.09 Pain Relevance 0
Gene amplification, autocrine or paracrine upregulation, altered receptor processing, ligand overexpression, and/or dysregulation of co-receptor dimerization each may represent a potential contributing factor.
co-receptor Binding (dimerization) of
2) Confidence 0.36 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.81 Pain Relevance 0
l recombinant human CD4 (hCD4), a glycoprotein coreceptor for gp120 [23], reconstituted in 0.1% BSA/PBS solution (100 ?
coreceptor Binding (recombinant) of
3) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.34 Pain Relevance 0.24
We found that the interaction of the patient's MuSK mutants with the co-receptor of agrin Lrp4 was not affected.
co-receptor Binding (interaction) of
4) Confidence 0.36 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.28 Pain Relevance 0

General Comments

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