INT279202

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.45
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
blood 2
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 100.00 Very High Very High Very High
chemokine 1 100.00 Very High Very High Very High
Inflammatory marker 3 99.92 Very High Very High Very High
Inflammatory response 1 99.92 Very High Very High Very High
Inflammation 32 82.40 Quite High
methotrexate 28 79.00 Quite High
Pain 6 78.24 Quite High
Inflammatory mediators 8 67.36 Quite High
metalloproteinase 2 64.48 Quite High
rheumatoid arthritis 28 44.44 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 44 99.74 Very High Very High Very High
Necrosis 5 96.80 Very High Very High Very High
Cancer 6 96.68 Very High Very High Very High
Thyroiditis 73 95.20 Very High Very High Very High
Aging 4 93.88 High High
Thyroid Disease 9 90.72 High High
Syndrome 3 84.40 Quite High
Frailty 8 84.04 Quite High
Rheumatoid Arthritis 28 44.44 Quite Low
Granuloma 2 43.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CRP secretion is increased in response to a complex network of cytokines, especially IL-6 and either IL-1 or tumor necrosis factor (TNF-?)
Positive_regulation (increased) of Localization (secretion) of CRP associated with necrosis, cancer and cytokine
1) Confidence 0.69 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2989710 Disease Relevance 1.36 Pain Relevance 0.21
In the phase III SATORI trial conducted in Japan, patients received 8 mg/kg every 4 weeks for 24 weeks, and the patients who were unable to achieve CRP normalization were those in whom tocilizumab could not be detected in blood at trough levels.
Neg (unable) Positive_regulation (achieve) of Localization (normalization) of CRP in blood
2) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0 Pain Relevance 0.13
participates in the innate acute inflammatory response by inducing the secretion of chemokines, which stimulate a second wave of cytokines, including IL-6, IL-8 and C-reactive protein [14,15].
Positive_regulation (inducing) of Localization (secretion) of C-reactive protein associated with chemokine, inflammatory response and cytokine
3) Confidence 0.10 Published 2010 Journal Trials Section Body Doc Link PMC2919525 Disease Relevance 1.09 Pain Relevance 0.38

General Comments

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