INT279236

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB2) plasma membrane (ITGB2) cell-cell signaling (ITGB2)
Anatomy Link Frequency
T cell 1
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 72 96.56 Very High Very High Very High
cytokine 9 43.76 Quite Low
Arthritis 9 36.64 Quite Low
Adalimumab 2 30.64 Quite Low
rheumatoid arthritis 7 27.00 Quite Low
Etanercept 37 22.48 Low Low
Infliximab 30 21.52 Low Low
Inflammation 16 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 91 96.56 Very High Very High Very High
Adhesions 3 88.04 High High
Disease 13 48.16 Quite Low
Seronegative Spondarthritis 8 36.64 Quite Low
Rheumatoid Arthritis 7 27.00 Quite Low
INFLAMMATION 17 5.00 Very Low Very Low Very Low
Infection 11 5.00 Very Low Very Low Very Low
Demyelinating Disease 6 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This binding maximally activates T cell functions (Hogg et al 2003), and it is specifically targeted by efalizumab, the humanized monoclonal antibody that binds to the CD11a portion of LFA-1 currently used as a relatively safe and effective biological drug for the therapy of psoriasis (Figure 2B).
Localization (portion) of LFA-1 in T cell associated with psoriasis
1) Confidence 0.17 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.43 Pain Relevance 0.14

General Comments

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