INT279242

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (GLA, SH3GL3) endosome (SH3GL3) small molecule metabolic process (GLA)
Golgi apparatus (GLA) lipid binding (SH3GL3) signal transduction (SH3GL3)
Anatomy Link Frequency
myocytes 2
GLA (Homo sapiens)
SH3GL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 1 5.76 Low Low
fibrosis 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Pain score 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fabry Disease 42 99.14 Very High Very High Very High
Left Ventricular Hypertrophy 3 81.52 Quite High
Cardiovascular Disorder Under Development 1 78.00 Quite High
Cv General 2 Under Development 3 75.92 Quite High
Arrhythmia Under Development 1 74.40 Quite High
Hypohidrosis 1 72.24 Quite High
Angiokeratoma 2 70.96 Quite High
Heart Rate Under Development 1 59.76 Quite High
Renal Disease 43 50.00 Quite Low
Chronic Renal Failure 20 45.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The “cardiac” variant of Fabry disease refers to patients who have some residual alpha-galactosidase A activity, with GL-3 deposition confined to myocytes, and as first described, do not manifest the whole spectrum of symptoms present in classical Fabry disease (von Scheidt et al 1991; Nakao et al 1995).
Negative_regulation (deposition) of alpha-galactosidase Binding (activity) of GL-3 in myocytes associated with fabry disease
1) Confidence 0.08 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 1.22 Pain Relevance 0

General Comments

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