INT279246

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.59
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (SH3GL3) endosome (SH3GL3) signal transduction (SH3GL3)
cytoplasm (SH3GL3)
Anatomy Link Frequency
plasma 2
SH3GL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 10 49.68 Quite Low
fibrosis 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Pain score 2 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 86 99.42 Very High Very High Very High
Fabry Disease 84 82.28 Quite High
Disease 52 81.08 Quite High
Proteinuria 170 6.28 Low Low
Chronic Renal Failure 40 5.00 Very Low Very Low Very Low
Fibrosis 12 5.00 Very Low Very Low Very Low
Sclerosis 12 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Albuminuria 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Critical issues that have to be addressed include: A) Are the beneficial effects of ERT on clinical outcomes in Fabry nephropathy are reflected in concordant changes in GL-3 load?
Positive_regulation (changes) of Gene_expression (load) of GL-3 associated with renal disease
1) Confidence 0.12 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.23 Pain Relevance 0
Males have higher plasma and urinary levels of GL-3 than females, and the plasma and urinary GL-3 levels correlate with each other, however, there is not correlation between elevated GL-3 levels and clinical symptoms (Vedder et al 2007).
Positive_regulation (elevated) of Gene_expression (levels) of GL-3 in plasma
2) Confidence 0.12 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 0.36 Pain Relevance 0

General Comments

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