INT279267

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.12
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RIPK2, CASP1) signal transduction (RIPK2, CASP1) intracellular (RIPK2, CASP1)
cytoplasm (RIPK2, CASP1) peptidase activity (CASP1) signal transducer activity (RIPK2)
RIPK2 (Homo sapiens)
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 22 100.00 Very High Very High Very High
anakinra 19 5.00 Very Low Very Low Very Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 100.00 Very High Very High Very High
Disease 20 99.88 Very High Very High Very High
Syndrome 113 92.96 High High
Exanthema 7 89.44 High High
Arthralgia 5 89.00 High High
Fever 8 87.60 High High
Apoptosis 1 68.68 Quite High
Cryopyrin-associated Periodic Syndromes 25 5.00 Very Low Very Low Very Low
Amyloidosis 11 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
as the principal consequence of CIAS1 mutations leading to the manifestation of the clinical disease, the CASP1 mutation appears to exert its pro-inflammatory effect by engaging RIP2, resulting in excessive activation of NF-?
RIP2 Binding (engaging) of Spec (appears) Positive_regulation (exert) of Gene_expression (mutation) of CASP1 associated with inflammation and disease
1) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.12 Pain Relevance 0.14

General Comments

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