INT279268

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (CARD8, CASP1) cytoplasm (CARD8, CASP1) cytosol (CASP1)
peptidase activity (CASP1) signal transduction (CASP1) nucleus (CARD8)
CARD8 (Homo sapiens)
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 22 14.24 Low Low
corticosteroid 1 10.88 Low Low
anakinra 19 5.00 Very Low Very Low Very Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 113 87.92 High High
Infection 2 86.48 High High
Crystal Associated Disease 2 73.28 Quite High
Cryopyrin-associated Periodic Syndromes 25 49.84 Quite Low
Disease 20 37.28 Quite Low
INFLAMMATION 22 14.24 Low Low
Amyloidosis 11 5.00 Very Low Very Low Very Low
Fever 8 5.00 Very Low Very Low Very Low
Exanthema 7 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This leads to activation of N-terminal domain and subsequent PYD-PYD homologous protein interaction leading to the recruitment of the ASC adaptor protein, which together with CARDINAL activates caspase-1, which, in turn cleaves pro-IL-1ß into its active form (Church et al 2008; Martinon et al 2002) (Figure 1).
CARDINAL Positive_regulation (activates) of caspase-1
1) Confidence 0.32 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.30 Pain Relevance 0

General Comments

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