INT279282

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (EGFR, ESR2) enzyme binding (EGFR, ESR2) signal transduction (EGFR, ESR2)
nucleoplasm (ESR2) mitochondrion (ESR2) DNA binding (ESR2)
EGFR (Homo sapiens)
ESR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 2 36.12 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 138 95.64 Very High Very High Very High
Metastasis 10 70.56 Quite High
Biliary Cancer 2 64.72 Quite High
Cancer 68 56.68 Quite High
Adenocarcinoma 2 49.36 Quite Low
Disease 18 42.52 Quite Low
Toxicity 2 32.36 Quite Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Solid Tumor 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rationale is that hetero-dimerization of EGFR with other members of the Erb family may contribute to the resistance against selective EGFR inhibitors.
EGFR Binding (hetero) of Erb
1) Confidence 0.45 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.70 Pain Relevance 0
The rationale is that hetero-dimerization of EGFR with other members of the Erb family may contribute to the resistance against selective EGFR inhibitors.
EGFR Binding (dimerization) of Erb
2) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.69 Pain Relevance 0

General Comments

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