INT279282

Context Info Confidence 0.45 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.39 Pain Relevance 0

nucleus (EGFR, ESR2) enzyme binding (EGFR, ESR2) signal transduction (EGFR, ESR2) nucleoplasm (ESR2) mitochondrion (ESR2) DNA binding (ESR2)

EGFR (Homo sapiens) ESR2 (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 2 36.12 cytokine 4 5.00 Pain 2 5.00 Potency 2 5.00

Disease Link Frequency Relevance Heat Pancreatic Cancer 138 95.64 Metastasis 10 70.56 Biliary Cancer 2 64.72 Cancer 68 56.68 Adenocarcinoma 2 49.36 Disease 18 42.52 Toxicity 2 32.36 Apoptosis 8 5.00 Solid Tumor 6 5.00 Congenital Anomalies 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The rationale is that hetero-dimerization of EGFR with other members of the Erb family may contribute to the resistance against selective EGFR inhibitors.

EGFR Binding (hetero) of Erb

1) Confidence 0.45 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.70 Pain Relevance 0

The rationale is that hetero-dimerization of EGFR with other members of the Erb family may contribute to the resistance against selective EGFR inhibitors.

EGFR Binding (dimerization) of Erb

2) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.69 Pain Relevance 0

General Comments

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