INT279286

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.35
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (TXK, VEGFA) DNA binding (TXK) extracellular space (VEGFA)
extracellular region (VEGFA) growth (VEGFA) proteinaceous extracellular matrix (VEGFA)
Anatomy Link Frequency
liver 2
TXK (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 72.36 Quite High
dexamethasone 16 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 73 100.00 Very High Very High Very High
Fibromyalgia 2 98.48 Very High Very High Very High
Solid Tumor 21 94.40 High High
Pancreatic Cancer 69 87.44 High High
Hypoxia 7 84.88 Quite High
Recurrence 3 83.24 Quite High
Adenocarcinoma 2 82.92 Quite High
Glioma 1 77.76 Quite High
Necrosis 1 75.96 Quite High
Hypoglycemia 1 66.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF signaling pathways have been targeted for treatment by the use of anti-VEGF monoclonal antibodies, antibodies binding to VEGFR and VEGFR tyrosine kinase inhibitors.
tyrosine kinase Binding (binding) of anti-VEGF
1) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.65 Pain Relevance 0.04
VEGF has a key, rate-limiting role in promoting tumor angiogenesis and exerts its effects by binding to one of three tyrosine kinase receptors: VEGF receptor-1 (VEGFR-1; fms-like tyrosine kinase-1, Flt-1), VEGFR-2 (human kinase domain region, KDR/murine fetal liver kinase-1, Flk-1) and VEGFR-3 (Flt-4).
tyrosine kinase Binding (binding) of VEGF in liver associated with fibromyalgia and cancer
2) Confidence 0.03 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 0.51 Pain Relevance 0
VEGF has a key, rate-limiting role in promoting tumor angiogenesis and exerts its effects by binding to one of three tyrosine kinase receptors (Figure 1): VEGF receptor-1 (VEGFR-1; fms-like tyrosine kinase-1, Flt-1), VEGFR-2 (human kinase domain region, KDR/murine fetal liver kinase-1, Flk-1), and VEGFR-3 (Flt-4).
tyrosine kinase Binding (binding) of VEGF in liver associated with fibromyalgia and cancer
3) Confidence 0.01 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.19 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox