INT279295

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.03 Pain Relevance 0.04

lyase activity (CA9) nucleolus (CA9) plasma membrane (CA9) nucleus (CA9)

CA9 (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 1 87.28 cytokine 2 5.00 Pain 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Cancer 34 100.00 Toxicity 1 97.36 Pancreatic Cancer 69 94.84 Disease 9 74.32 Diarrhoea 1 38.28 Exanthema 1 37.76 Biliary Cancer 1 30.48 Metastasis 5 18.48 Apoptosis 4 5.00 Solid Tumor 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Primary endpoint of the study was CA19-9 response (>50% decrease in tumor marker CA19-9 levels) with additional endpoints including radiologic response, toxicity, and survival.

Regulation (response) of Negative_regulation (decrease) of CA19-9 associated with toxicity and cancer

1) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.03 Pain Relevance 0.04

General Comments

This test has worked.