INT279296

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.71
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
Anatomy Link Frequency
Platelet 1
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 84.80 Quite High
cva 4 72.88 Quite High
Potency 2 62.28 Quite High
nud 1 54.96 Quite High
Pain 13 48.88 Quite Low
Analgesic 3 46.48 Quite Low
positron emission tomography 4 31.44 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 138 99.84 Very High Very High Very High
Cancer 167 99.04 Very High Very High Very High
Fatigue 9 94.24 High High
Ovarian Cancer 104 83.92 Quite High
Disease 70 80.72 Quite High
Carcinoma 3 75.40 Quite High
Death 5 73.96 Quite High
Cv General 3 Under Development 3 72.88 Quite High
Solid Tumor 15 71.04 Quite High
Injury 2 68.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet-derived growth factor ligands, PDGF-A and PDGF-B, exert their effects on target cells by activating the two structurally related protein tyrosine kinase receptors, PDGFR-?
Localization (related) of PDGFR in Platelet
1) Confidence 0.54 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.49 Pain Relevance 0.03
PDGFR targeting in pancreatic cancer
Localization (targeting) of PDGFR associated with pancreatic cancer
2) Confidence 0.47 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.40 Pain Relevance 0.03
Combination approaches targeting the VEGF/VEGFR and the PDGF/PDGFR axes are thus very appealing [67].


Localization (targeting) of PDGFR
3) Confidence 0.37 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.92 Pain Relevance 0.03
Paraffin-embedded blocks of the three negative patients were referred to the Department of Pathology of National Cancer Institute of Milan (Italy) for determining the presence of PDGFR-?
Localization (presence) of PDGFR associated with cancer
4) Confidence 0.23 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2828414 Disease Relevance 0.89 Pain Relevance 0.16

General Comments

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