INT279298

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.50
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JAK1) cytoskeleton (JAK1) nucleus (JAK1)
cytoplasm (JAK1)
Anatomy Link Frequency
T cells 1
JAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 45 93.40 High High
Fibrositis 54 75.24 Quite High
Potency 2 48.92 Quite Low
Pain 11 45.76 Quite Low
Inflammation 7 35.44 Quite Low
Chronic pancreatitis 6 31.64 Quite Low
Opioid 12 5.00 Very Low Very Low Very Low
drug abuse 7 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 135 99.72 Very High Very High Very High
Hepatitis C Virus Infection 234 99.52 Very High Very High Very High
Opiate Addiction 158 99.34 Very High Very High Very High
Pancreatic Cancer 146 96.16 Very High Very High Very High
Hypoxia 4 94.88 High High
Congenital Anomalies 7 91.12 High High
Cancer 141 90.04 High High
Adenocarcinoma 45 87.52 High High
Fatigue 7 80.88 Quite High
Apoptosis 11 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When IL-6 binds to its receptor, a mechanism is triggered blocking Janus Kinase signal and activator of transcription (JAK/STAT) mediated transcription of IL-1 and TNF-?
Gene_expression (signal) of Janus Kinase
1) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2891797 Disease Relevance 0.65 Pain Relevance 0.37
In contrast, the growth of JAK1-transfected SKN cells, which had strong exogenous JAK1 activity, was prevented by IFN-?
Gene_expression (growth) of JAK1
2) Confidence 0.47 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.37 Pain Relevance 0
, Ras/MAPK, Src kinase and Jak/Stat kinase pathways.
Gene_expression (kinase) of Jak
3) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.49 Pain Relevance 0
They consist of eight families with the major ones including SRC, JAK, ABL, FAK (Levitzki 1999).


Gene_expression (ones) of JAK
4) Confidence 0.09 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.34 Pain Relevance 0
To investigate whether heroin use or heroin use plus HCV infection has an impact on IL-12 pathway in CD56+ T cells, the transcriptional expression of key elements [IL-12 receptors, signal transducer and activator of transcription (STAT)-1, 3, 4, 5, janus kinase (JAK)-2, and tyrosine kinase (TYK)-2] in IL-12 pathway in CD56+ T cells was analyzed by the real-time RT PCR.
Gene_expression (expression) of JAK in T cells associated with hepatitis c virus infection, opiate addiction and infection
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.51 Pain Relevance 0
IL18, OAS genes) or directly involved in IFN signaling (JAK/STAT), STAT1 and OAS1, OAS2, OAS3 and MxA best distinguished the two phenotypes.


Gene_expression (signaling) of JAK
6) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.35 Pain Relevance 0
We thus investigated whether heroin use or heroin use plus HCV infection suppress the expression of the key elements in JAK/STAT pathway.
Gene_expression (expression) of JAK associated with hepatitis c virus infection, opiate addiction and infection
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 0.79 Pain Relevance 0

General Comments

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