INT27933

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Context Info
Confidence 0.72
First Reported 1981
Last Reported 2011
Negated 0
Speculated 3
Reported most in Body
Documents 65
Total Number 71
Disease Relevance 31.35
Pain Relevance 24.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2)
nucleus (NCOR2) DNA binding (NCOR2)
Anatomy Link Frequency
brain 4
macrophages 2
fascicles 2
spinal cord 2
SH-SY5Y 1
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 818 100.00 Very High Very High Very High
chemokine 147 100.00 Very High Very High Very High
opioid receptor 133 100.00 Very High Very High Very High
Serotonin 12 100.00 Very High Very High Very High
Kappa opioid receptor 5 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Opioid 230 99.88 Very High Very High Very High
unmyelinated 342 99.86 Very High Very High Very High
Glutamate receptor 14 99.76 Very High Very High Very High
spinal dorsal horn 19 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 903 100.00 Very High Very High Very High
Pancreatic Cancer 405 99.84 Very High Very High Very High
Breast Cancer 260 99.84 Very High Very High Very High
Anaplastic Astrocytoma 28 99.84 Very High Very High Very High
Carcinoma 43 99.80 Very High Very High Very High
Cancer 1741 99.76 Very High Very High Very High
Neuroblastoma 4 99.72 Very High Very High Very High
Neuropathic Pain 38 99.56 Very High Very High Very High
Disease 447 99.40 Very High Very High Very High
Adenocarcinoma 66 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(B) RT-qPCR analysis of NCOR1 and SMRT expression 6?
Gene_expression (expression) of SMRT
1) Confidence 0.72 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3017614 Disease Relevance 0.08 Pain Relevance 0
As shown in Figure 7A (left), the treatment of WI38 cells with NCOR2 siRNA reduced NCOR2 expression to 28–46% relative to cells exposed to control siRNA.
Gene_expression (expression) of NCOR2
2) Confidence 0.72 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3017614 Disease Relevance 0.09 Pain Relevance 0
Using the reverse transcription-polymerase chain reaction, the expression patterns of all cloned G-protein-coupled serotonin receptors were analysed in various human meningeal tissues.
Spec (analysed) Gene_expression (expression) of receptors associated with serotonin
3) Confidence 0.64 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8743744 Disease Relevance 0.47 Pain Relevance 0.97
This correlates well with the observed changes in ANGPTL4 expression, pointing to a causal relationship between the regulation of class A genes and the recruitment of SMRT in response to TGF?
Gene_expression (recruitment) of SMRT
4) Confidence 0.62 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3017614 Disease Relevance 0.07 Pain Relevance 0
-induced expression of SMRT, the impact of TGF?
Gene_expression (expression) of SMRT
5) Confidence 0.56 Published 2011 Journal Nucleic Acids Research Section Body Doc Link PMC3017614 Disease Relevance 0.14 Pain Relevance 0.07
Recently, it has been shown that elevated SMRT levels result in suppression of target genes for the vitamin D receptor (VDR) in prostate cancer cells and in apparent hormonal insensitivity (Khanim et al. 2004).
Gene_expression (levels) of SMRT associated with reprotox - general 1
6) Confidence 0.53 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.15 Pain Relevance 0.03
In this study, we show that a very high density of sigma receptors is also expressed in an androgen-independent human prostate tumor cell line (DU-145).
Gene_expression (expressed) of receptors associated with prostate cancer
7) Confidence 0.48 Published 1999 Journal Cancer Res. Section Abstract Doc Link 10493511 Disease Relevance 0.54 Pain Relevance 0.09
Sigma receptors are known to be expressed in a variety of human tumor cells, including breast, neural, and melanoma tumors.
Gene_expression (expressed) of receptors in neural associated with cancer and skin cancer
8) Confidence 0.48 Published 1999 Journal Cancer Res. Section Abstract Doc Link 10493511 Disease Relevance 0.52 Pain Relevance 0.06
However, the distinct amplicon at 8q13.3 in ZR-75-30 detected by SMRT array CGH was missed in this study.
Gene_expression (detected) of SMRT array CGH in ZR-75-30
9) Confidence 0.46 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.29 Pain Relevance 0.13
Further comparison of SNP data and SMRT array CGH for cell line BT-474 showed that many of the alterations detected by SMRT array CGH were not clearly delineated or were not detected by the SNP platform (Additional file 9).
Gene_expression (detected) of SMRT array CGH in BT-474
10) Confidence 0.40 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0 Pain Relevance 0
Besides, Valdes have tested polymorphisms of genes that express inflammatory factors, and found some of the same polymorphisms, such as CD36, COX2, NCOR2, TNA and ESR1, affecting knee OA susceptibility, were also associated with radiographic progression of lumbar disc degeneration 56.
Gene_expression (express) of NCOR2 in knee associated with intervertebral disk degeneration, inflammation and cox2
11) Confidence 0.25 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 1.09 Pain Relevance 0.52
Thus HeLa cells express most of coactivators described so far, and SMRT was found to be expressed at significant levels.
Gene_expression (expressed) of SMRT in HeLa
12) Confidence 0.25 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0 Pain Relevance 0
Among these two corepressors, only SMRT/TRAC2 was found to be significantly expressed.
Gene_expression (expressed) of SMRT
13) Confidence 0.25 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0 Pain Relevance 0
Expression levels of nuclear corepressors N-CoR [27] and SMRT [28] were also assessed (Figure 1D).
Gene_expression (Expression) of SMRT
14) Confidence 0.17 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0 Pain Relevance 0
Natural and antibody-dependent cellular cytotoxicity in tumour-adherent T lymphocytes: expression of Fc receptors and of a human T-subgroup-specific antigen.
Gene_expression (expression) of receptors in T lymphocytes associated with cancer
15) Confidence 0.12 Published 1981 Journal Scand. J. Immunol. Section Title Doc Link 6179156 Disease Relevance 0.71 Pain Relevance 0.09
The recent development of S-2-methyl-4-carboxyphenylglycine as an antagonist which is highly selective for metabotropic glutamate receptor-1 compared to metabotropic glutamate receptor-5 on human receptors expressed in AV-12 cells, now offers the possibility of discriminating between these two receptor subtypes in order to distinguish which is involved in thalamic responses.
Gene_expression (expressed) of receptors associated with glutamate receptor and antagonist
16) Confidence 0.12 Published 1998 Journal Neuroscience Section Abstract Doc Link 9639261 Disease Relevance 0 Pain Relevance 0.62
We have measured the selectivity of tilidine and nortilidine for human opioid and opioid-like receptors stably expressed in CHO-K1 cells, using the inhibition of the forskolin (FK)-induced accumulation of cAMP as endpoint.
Gene_expression (expressed) of receptors associated with opioid
17) Confidence 0.06 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15627429 Disease Relevance 0.08 Pain Relevance 0.90
In this study we have used SH-SY5Y human neuroblastoma cells, which express both mu and delta receptors, to examine the effects of halothane on the receptor binding profiles of [3H]diprenorphine (DPN), an opioid receptor antagonist, and [3H] [D-Ala2,MePhe4, Gly(ol)5]enkephalin (DAMGO), a mu receptor selective agonist.
Spec (examine) Gene_expression (express) of receptors in SH-SY5Y associated with neuroblastoma, antagonist, agonist, enkephalin, opioid receptor and halothane
18) Confidence 0.06 Published 1995 Journal Br J Anaesth Section Abstract Doc Link 8672325 Disease Relevance 0.17 Pain Relevance 0.62
For example, NcoR a silencing
Gene_expression (silencing) of NcoR
19) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.18 Pain Relevance 0.03
On one level, this treatment is effective because it directly replaces the substance that is withdrawn from the patient, resetting brain receptors with equal potency.
Gene_expression (resetting) of receptors in brain associated with potency
20) Confidence 0.04 Published 2000 Journal Crit Care Section Body Doc Link PMC137331 Disease Relevance 0.50 Pain Relevance 0.37

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