INT27936

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Context Info
Confidence 0.41
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.28
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Klkb1) extracellular space (Klkb1) extracellular region (Klkb1)
Anatomy Link Frequency
dendrites 2
Plasma 2
neural 2
Klkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 413 100.00 Very High Very High Very High
headache 3 99.88 Very High Very High Very High
imagery 60 97.76 Very High Very High Very High
Multiple sclerosis 6 93.56 High High
Pyramidal cell 19 88.48 High High
unmyelinated 16 87.60 High High
intrathecal 3 75.04 Quite High
depression 1 68.92 Quite High
Inflammation 1 58.00 Quite High
Hippocampus 2 37.36 Quite Low
Disease Link Frequency Relevance Heat
Headache 3 99.88 Very High Very High Very High
Viral Meningitis 5 95.52 Very High Very High Very High
Demyelinating Disease 6 93.56 High High
Targeted Disruption 2 75.96 Quite High
Depression 1 68.92 Quite High
Pain 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low
Neurological Disease 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Splitting is caused by gradual conduction fluctuations and jump-like events acting together in a structured manner, such as to systematically accelerate or decelerate APs within an AP set as it propagates along the axon.
Positive_regulation (decelerate) of Gene_expression (decelerate) of APs associated with action potential
1) Confidence 0.41 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.26
More often than not, channel noise has the opposite effect of promoting AP generation (e.g., additional spontaneous APs, stochastic microsaltatory conduction).
Positive_regulation (promoting) of Gene_expression (generation) of APs associated with action potential
2) Confidence 0.38 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.31
APs cause Ca2+ accumulations in somata and dendrites that can be detected with Ca2+ imaging in vivo [49,90,97].
Positive_regulation (accumulations) of Gene_expression (cause) of APs in dendrites associated with action potential and imagery
3) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1914403 Disease Relevance 0.07 Pain Relevance 0.37
Comprehensive analysis of neural circuits will require reliable detection of single APs as well as estimation of the firing frequency during bursts of APs.
Positive_regulation (require) of Gene_expression (detection) of APs in neural
4) Confidence 0.19 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0.08 Pain Relevance 0.13
Plasma levels of beta 2m increased with age in TH controls, particularly in the older age group, while no significant age variation could be detected for CSF beta 2m.
Positive_regulation (increased) of Gene_expression (levels) of Plasma in Plasma associated with headache
5) Confidence 0.00 Published 1989 Journal Acta Neurol. Scand. Section Abstract Doc Link 2694730 Disease Relevance 1.14 Pain Relevance 0.67

General Comments

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