INT279360

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ADA, IFNG) small molecule metabolic process (ADA) aging (ADA)
cytoplasm (ADA) cytosol (ADA) extracellular region (IFNG)
Anatomy Link Frequency
blood 2
ADA (Homo sapiens)
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 211 100.00 Very High Very High Very High
cytokine 4 100.00 Very High Very High Very High
metalloproteinase 1 97.20 Very High Very High Very High
rheumatoid arthritis 20 90.28 High High
Infliximab 65 49.84 Quite Low
Inflammation 11 19.88 Low Low
corticosteroid 20 5.00 Very Low Very Low Very Low
methotrexate 7 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 96.60 Very High Very High Very High
Rheumatoid Arthritis 20 90.28 High High
Disease 99 80.24 Quite High
Adhesions 1 74.24 Quite High
Inflammatory Bowel Disease 11 20.44 Low Low
Fistula 14 5.00 Very Low Very Low Very Low
Systemic Lupus Erythematosus 9 5.00 Very Low Very Low Very Low
Mycobacterial Infection 8 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, ADA was able to influence in vitro monocyte cytokine production (down-regulation of IL-10 and 12) (Shen et al 2005), to inhibit antigen-induced IFN-gamma production (Saliu et al 2006), to enhance the production of tissue inhibitor of metalloproteinases (TIMP)-1 (Di Sabatino et al 2007), and to increase the number and function of peripheral blood T regulatory cells (T-regs) from baseline in patients with RA (Vigna-PĂ©rez et al 2005).
ADA Negative_regulation (inhibit) of Gene_expression (production) of IFN-gamma in blood associated with rheumatoid arthritis, metalloproteinase, adalimumab and cytokine
1) Confidence 0.06 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.51 Pain Relevance 0.44

General Comments

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