INT279361

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.72
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (TNF, KLF1) DNA binding (KLF1) extracellular matrix organization (TNF)
extracellular space (TNF) signal transduction (TNF) extracellular region (TNF)
TNF (Homo sapiens)
KLF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 210 100.00 Very High Very High Very High
Adalimumab 641 99.26 Very High Very High Very High
cytokine 38 97.28 Very High Very High Very High
Inflammation 40 94.64 High High
rheumatoid arthritis 64 94.12 High High
psoriasis 68 84.80 Quite High
Arthritis 13 81.04 Quite High
spinal inflammation 7 80.16 Quite High
Multiple sclerosis 9 79.88 Quite High
Etanercept 19 64.92 Quite High
Disease Link Frequency Relevance Heat
Disease 312 97.00 Very High Very High Very High
INFLAMMATION 27 94.64 High High
Rheumatoid Arthritis 64 94.12 High High
Psoriasis 76 93.52 High High
Inflammatory Bowel Disease 33 91.60 High High
Serum Sickness 4 83.56 Quite High
Seronegative Spondarthritis 9 81.84 Quite High
Lymphatic System Cancer 8 81.24 Quite High
Malignant Neoplastic Disease 5 80.48 Quite High
Low Back Pain 7 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adalimumab (ADA) is a subcutaneously administered, recombinant, fully human, IgG1 monoclonal antibody that binds with high affinity and specificity to human TNF-alpha, thus modulating its biologic functions and its proinflammatory effects.


TNF Binding (binds) of monoclonal associated with adalimumab
1) Confidence 0.00 Published 2008 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2727899 Disease Relevance 0.68 Pain Relevance 0.37
First named D2E7, ADA (Humira®; Abbott Laboratories, Abbott Park, IL, USA) is a subcutaneously administered, recombinant, fully human, IgG1 monoclonal antibody that binds with high affinity and specificity to human TNF-alpha, thus modulating its biologic functions (Plosker and Lyseng-Williamson 2007).
TNF Binding (binds) of monoclonal associated with adalimumab
2) Confidence 0.00 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.63 Pain Relevance 0.49
ADA is a recombinant, fully human, IgG1 monoclonal antibody that binds specifically to TNF-alpha, but not lymphotoxin, thereby neutralizing the effect of the cytokine by blocking its interaction with p55 and p75 cell surface TNF receptors (Tracey et al 2008).
TNF Binding (binds) of monoclonal associated with adalimumab and cytokine
3) Confidence 0.00 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.81 Pain Relevance 0.56
monoclonal antibody, which is similar to infliximab, binds soluble and transmembrane TNF-?.
TNF Binding (binds) of monoclonal associated with infliximab
4) Confidence 0.00 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 1.60 Pain Relevance 0.77

General Comments

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