INT279366

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 4.37
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ADA) aging (ADA) cytoplasm (ADA)
cytosol (ADA) extracellular space (ADA) cell adhesion (ADA)
Anatomy Link Frequency
visceral 2
Monocyte 2
ADA (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 211 100.00 Very High Very High Very High
Infliximab 65 100.00 Very High Very High Very High
Inflammation 15 99.80 Very High Very High Very High
Etanercept 2 87.76 High High
antagonist 5 54.68 Quite High
rheumatoid arthritis 22 52.72 Quite High
adenocard 20 50.00 Quite Low
corticosteroid 20 23.88 Low Low
cva 10 5.00 Very Low Very Low Very Low
methotrexate 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 121 99.98 Very High Very High Very High
Fever 119 99.92 Very High Very High Very High
Communicable Diseases 8 99.84 Very High Very High Very High
INFLAMMATION 13 99.80 Very High Very High Very High
Infection 29 99.46 Very High Very High Very High
Bacterial Pneumonia 4 98.32 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 97.48 Very High Very High Very High
Mycobacterial Infection 14 96.08 Very High Very High Very High
Leishmaniasis 6 95.12 Very High Very High Very High
Systemic Lupus Erythematosus 9 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not known, however, when these patients became ANA positive, as it appears these measurements were not conducted during or after IFX therapy nor before ADA use.
Neg (nor) Positive_regulation (conducted) of Localization (use) of ADA associated with infliximab and adalimumab
1) Confidence 0.42 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 1.45 Pain Relevance 0.66
Increased serum ADA has been reported in infectious diseases such as viral and bacterial pneumonia, HIV infection, extra-pulmonary and pulmonary tuberculosis, visceral leishmaniasis, and mononucleosis.21,22,25
Positive_regulation (Increased) of Localization (reported) of serum ADA in visceral associated with leishmaniasis, mycobacterial infection, bacterial pneumonia, acquired immune deficiency syndrome or hiv infection, communicable diseases and infection
2) Confidence 0.41 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.45 Pain Relevance 0.05
It seems to be associated with the differentiation of epithelial cells and monocytes and with neurotransmission.33 Monocyte/macrophage activation by intracellular infection and inflammatory diseases leads to the release of ADA and elevated levels in the serum.34 Monocyte involvement in CCHF has been well described.19 However, no studies have reported the ADA/XO levels in patients with CCHF.
Positive_regulation (leads) of Localization (release) of ADA in Monocyte associated with inflammation, fever, disease and infection
3) Confidence 0.38 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910858 Disease Relevance 1.46 Pain Relevance 0.05

General Comments

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