INT279367

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
blood 2
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 99.64 Very High Very High Very High
Adalimumab 211 98.66 Very High Very High Very High
metalloproteinase 1 94.20 High High
rheumatoid arthritis 20 87.28 High High
Infliximab 65 43.84 Quite Low
Inflammation 11 17.08 Low Low
corticosteroid 20 5.00 Very Low Very Low Very Low
methotrexate 7 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 93.80 High High
Rheumatoid Arthritis 20 87.28 High High
Disease 99 77.44 Quite High
Adhesions 1 71.44 Quite High
Inflammatory Bowel Disease 11 17.64 Low Low
Fistula 14 5.00 Very Low Very Low Very Low
Systemic Lupus Erythematosus 9 5.00 Very Low Very Low Very Low
Mycobacterial Infection 8 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, ADA was able to influence in vitro monocyte cytokine production (down-regulation of IL-10 and 12) (Shen et al 2005), to inhibit antigen-induced IFN-gamma production (Saliu et al 2006), to enhance the production of tissue inhibitor of metalloproteinases (TIMP)-1 (Di Sabatino et al 2007), and to increase the number and function of peripheral blood T regulatory cells (T-regs) from baseline in patients with RA (Vigna-PĂ©rez et al 2005).
Negative_regulation (regulation) of Regulation (regulation) of IL-10 in blood associated with rheumatoid arthritis, metalloproteinase, adalimumab and cytokine
1) Confidence 0.06 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.49 Pain Relevance 0.39

General Comments

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