INT27937

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Context Info
Confidence 0.55
First Reported 1989
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 1.86
Pain Relevance 10.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Klkb1) extracellular space (Klkb1) extracellular region (Klkb1)
Anatomy Link Frequency
neurons 4
dendrites 2
neuronal 1
pyramidal cell 1
Plasma 1
Klkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 2513 100.00 Very High Very High Very High
headache 3 99.88 Very High Very High Very High
Pyramidal cell 122 99.58 Very High Very High Very High
tetrodotoxin 62 97.44 Very High Very High Very High
imagery 440 97.00 Very High Very High Very High
sodium channel 35 96.96 Very High Very High Very High
unmyelinated 88 96.84 Very High Very High Very High
nav1.8 56 95.46 Very High Very High Very High
dorsal root ganglion 49 95.06 Very High Very High Very High
Multiple sclerosis 18 93.56 High High
Disease Link Frequency Relevance Heat
Headache 3 99.88 Very High Very High Very High
Viral Meningitis 5 95.52 Very High Very High Very High
Ganglion Cysts 49 95.06 Very High Very High Very High
Demyelinating Disease 36 93.56 High High
Infection 38 80.32 Quite High
Targeted Disruption 20 75.28 Quite High
Depression 10 68.92 Quite High
Pneumonia 6 50.00 Quite Low
Shock 8 49.60 Quite Low
Pain 23 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The timing of APs within each set is not unique, but becomes unimodal (Figure 1, arrows A,B,C), or markedly multimodally distributed—forming visually distinct groups of APs (Figure 1, AP sets marked E).
Gene_expression (sets) of APs associated with action potential
1) Confidence 0.55 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.72
Splitting is caused by gradual conduction fluctuations and jump-like events acting together in a structured manner, such as to systematically accelerate or decelerate APs within an AP set as it propagates along the axon.
Gene_expression (decelerate) of APs associated with action potential
2) Confidence 0.55 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.26
Experimentally, thin pyramidal cell axons were found to conduct APs reliably [39,40].
Gene_expression (conduct) of APs in pyramidal cell associated with action potential and pyramidal cell
3) Confidence 0.55 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.41
To this end we triggered single APs in both axon models at various diameters and recorded the time series of the membrane potential and the number of open channels in narrowly spaced axon sections (spacing was

of the axon's length constant, all diameter and parameter variations kept this spacing <20 ?

Gene_expression (single) of APs associated with action potential
4) Confidence 0.55 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.33
For the same reasons, dendrites that support backpropagating APs and dendritic AP initiation are typically thicker then 0.5 ?
Gene_expression (backpropagating) of APs in dendrites associated with action potential
5) Confidence 0.55 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.24
APs generated by the same stimulus are not precisely aligned across trials, and the misalignment in the AP set grows considerably the further APs propagate.
Neg (not) Gene_expression (aligned) of APs associated with action potential
6) Confidence 0.55 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.37
Additional APs may appear spontaneously; however, APs in general seldom fail (<1%).
Gene_expression (appear) of APs associated with action potential
7) Confidence 0.55 Published 2007 Journal PLoS Computational Biology Section Abstract Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.18
These results were extrapolated to axons, where the axial current driving the AP was regarded as strong driving input, and, hence, it was inferred that APs should propagate very reliably in axons [9].
Gene_expression (propagate) of APs associated with action potential
8) Confidence 0.55 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.26
In both types of axon, varying membrane parameters (axoplasmic resistance ±50%, membrane resistance ±50%, resting potential ±5.5 mV, temperature ±50%) and ion channel parameters (Na channel density ±50%, Na single channel conductance ±50%, K channel density ±50%, K single channel conductance ±50%) results in either all four stochastic effects being still observed, or the axon becoming so noisy that it is unsuitable for communication, or the axon failing to produce APs.
Gene_expression (produce) of APs associated with action potential
9) Confidence 0.55 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.13
2) APs were thought to jump from Na channel to Na channel in 0.1-?
Gene_expression (thought) of APs associated with action potential
10) Confidence 0.55 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.30
More often than not, channel noise has the opposite effect of promoting AP generation (e.g., additional spontaneous APs, stochastic microsaltatory conduction).
Gene_expression (generation) of APs associated with action potential
11) Confidence 0.49 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.31
We developed algorithms to identify the neurons in which individual APs can be reliably detected based on fluorescence measurements, and to separate successes and failures in these cells.
Gene_expression (detected) of APs in neurons associated with action potential
12) Confidence 0.43 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1914403 Disease Relevance 0 Pain Relevance 0.08
The signals were recorded using a patch-clamp amplifier (Axoclamp 200B; Axon Instruments, http://www.axon.com/), and APs were detected using thresholding [61].
Gene_expression (detected) of APs associated with action potential
13) Confidence 0.42 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1914403 Disease Relevance 0 Pain Relevance 0.05
Nevertheless, in about half of the imaged neurons, we were not able to detect APs reliably without introducing considerable error rates (>0.5%).
Neg (without) Gene_expression (detect) of APs in neurons associated with action potential
14) Confidence 0.37 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1914403 Disease Relevance 0 Pain Relevance 0.25
We note that our approach for detecting single APs relies on the low firing rates seen in the barrel cortex [32].
Gene_expression (detecting) of APs in barrel cortex associated with action potential
15) Confidence 0.37 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1914403 Disease Relevance 0 Pain Relevance 0.21
APs cause Ca2+ accumulations in somata and dendrites that can be detected with Ca2+ imaging in vivo [49,90,97].
Gene_expression (cause) of APs in dendrites associated with action potential and imagery
16) Confidence 0.37 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1914403 Disease Relevance 0.07 Pain Relevance 0.37
Here, we used bulk loading of Ca2+ indicators and two-photon microscopy to detect APs in multiple neurons.
Gene_expression (detect) of APs in neurons associated with action potential
17) Confidence 0.33 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1914403 Disease Relevance 0 Pain Relevance 0.26
A variety of cardiac APs are observed in beating and nonbeating cells (Figure 6A and 6B), which both show a resting membrane potential of approximately ?
Gene_expression (variety) of APs associated with action potential
18) Confidence 0.26 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1064849 Disease Relevance 0 Pain Relevance 0.23
In many cases, single APs were associated with clear ?
Gene_expression (single) of APs
19) Confidence 0.26 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0 Pain Relevance 0.37
Single APs evoked Ca2+ transients with an average ?
Gene_expression (evoked) of APs
20) Confidence 0.26 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0 Pain Relevance 0.33

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