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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.35
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ddit3) cell cycle (Ddit3) DNA binding (Ddit3)
transcription factor binding (Ddit3) cytoplasm (Ddit3)
Anatomy Link Frequency
arm 1
Ddit3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 71.52 Quite High
vincristine 3 57.52 Quite High
tolerance 6 31.80 Quite Low
methotrexate 3 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
intrathecal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 129 99.20 Very High Very High Very High
Apoptosis 3 98.48 Very High Very High Very High
Death 2 97.56 Very High Very High Very High
Lymphatic System Cancer 82 93.60 High High
Stress 4 89.80 High High
Mantle-cell Lymphoma 13 78.52 Quite High
Follicular Lymphoma 13 77.56 Quite High
INFLAMMATION 1 71.52 Quite High
Hyperglycemia 4 61.48 Quite High
Polyuria 1 57.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ORRs were similar, but median TTP was significantly reduced in the CHOP arm (2.6 years).
Negative_regulation (reduced) of CHOP in arm
1) Confidence 0.30 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727901 Disease Relevance 0.31 Pain Relevance 0.03
In this regard, the development of diabetes is delayed by 8–10 weeks in Akita mice lacking CHOP highlighting the role of the UPR and apoptosis in beta-cell death in this model.
Negative_regulation (lacking) of CHOP associated with diabetes mellitus, apoptosis and death
2) Confidence 0.18 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 1.03 Pain Relevance 0.04

General Comments

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