INT27938

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Context Info
Confidence 0.38
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 1.98
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
epithelium 3
stroma 1
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 1 99.98 Very High Very High Very High
agonist 71 99.72 Very High Very High Very High
cocaine 6 96.64 Very High Very High Very High
antagonist 6 95.32 Very High Very High Very High
anesthesia 15 89.32 High High
Serotonin 1 77.52 Quite High
Substantia nigra 1 70.24 Quite High
Nucleus accumbens 2 68.56 Quite High
drug abuse 1 62.44 Quite High
depression 1 43.76 Quite Low
Disease Link Frequency Relevance Heat
Incomplete Abortion 2 99.00 Very High Very High Very High
Spontaneous Abortion 5 96.04 Very High Very High Very High
Targeted Disruption 48 90.40 High High
Anxiety Disorder 10 85.84 High High
Breast Cancer 12 84.32 Quite High
Stroke 1 75.96 Quite High
Drug Dependence 1 62.44 Quite High
Depression 2 43.76 Quite Low
Frailty 3 39.20 Quite Low
Reprotox - General 1 3 36.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infusion of further amounts of the CNS depressants caused a dose-dependent decrease of HR, CO and BP but did not influence SV whereas PR declined but did not fall considerably beyond the values in awake rats.
Negative_regulation (declined) of PR
1) Confidence 0.38 Published 1980 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7436631 Disease Relevance 0.08 Pain Relevance 0.09
Also, since ER regulates synthesis of the progesterone receptor (PR), it is possible that antagonism of ER by tamoxifen results in PR downregulation and that PR may be involved in exocytosis of glycogen from the vaginal epithelium.
Negative_regulation (downregulation) of PR in epithelium
2) Confidence 0.34 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.06 Pain Relevance 0
In addition, we found that DPN also decreased the PRAB immunostaining of GE, which indicate that the decrease in PR mRNA levels could be most pronounced, or selective, in the GE.
Negative_regulation (decrease) of PR
3) Confidence 0.34 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.09 Pain Relevance 0
Interestingly, buspirone and fluoxetine decreased PR responding in HG rats only and thereby abolished the individual differences in PR responding between HG and LG rats.
Negative_regulation (decreased) of PR associated with fluoxetine
4) Confidence 0.26 Published 2004 Journal Neuroscience Section Abstract Doc Link 15450359 Disease Relevance 0.34 Pain Relevance 0.55
The elegant experiments performed by Kurita et al. on tissue cultures of stroma and epithelium from different combinations of wt and ERaKO suggest that E2 induced down-regulation of epithelial PR in the uterus is mediated through paracrine mechanisms mediated via ER?
Negative_regulation (regulation) of epithelial PR in epithelium
5) Confidence 0.25 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.24 Pain Relevance 0
The ERbeta agonist DPN caused a decrease of the PR mRNA levels, which was also found for PRAB and PRB immunostaining in the GE.


Negative_regulation (decrease) of PR associated with agonist
6) Confidence 0.25 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.23
signalling decrease the PR mRNA levels, possibly selectively in the GE since in this structure the PR protein is also down regulated after DPN treatment.
Negative_regulation (decrease) of PR
7) Confidence 0.25 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.17 Pain Relevance 0
It has been shown that immunohistochemical staining of uterine PR decrease in epithelial cells after E2 treatment in immature mice, in agreement with our results on ovx rats, and those from ER?
Negative_regulation (decrease) of PR in epithelial cells
8) Confidence 0.22 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.28 Pain Relevance 0
As blockage of the progesterone receptor increases the myometrial sensitivity to prostaglandins, a combination of RU 486 and a prostaglandin E2-analogue was tested for termination of pregnancy.
Negative_regulation (blockage) of progesterone receptor associated with spontaneous abortion
9) Confidence 0.13 Published 1989 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 2694744 Disease Relevance 0.39 Pain Relevance 0
In previously untreated postmenopausal women, fulvestrant brought about dose-dependent reductions in ER and progesterone receptor (PgR) protein concentrations and produced no demonstrable estrogen agonist effect.
Negative_regulation (reductions) of PgR associated with agonist
10) Confidence 0.09 Published 2002 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 12353819 Disease Relevance 0.08 Pain Relevance 0.18
The elegant experiments performed by Kurita et al. on tissue cultures of stroma and epithelium from different combinations of wt and ERaKO suggest that E2 induced down-regulation of epithelial PR in the uterus is mediated through paracrine mechanisms mediated via ER?
Negative_regulation (regulation) of epithelial PR in stroma
11) Confidence 0.08 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.24 Pain Relevance 0
This was correlated with reduced inductive effects of E2 on progesterone receptor and IGF-1.
Negative_regulation (reduced) of progesterone receptor
12) Confidence 0.01 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174398 Disease Relevance 0 Pain Relevance 0

General Comments

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