INT279380

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.66
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ttpa) transport (Ttpa) intracellular (Ttpa)
cytoplasm (Ttpa)
Anatomy Link Frequency
arm 1
Ttpa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 464 93.40 High High
cytokine 132 86.08 High High
Inflammatory stimuli 12 83.60 Quite High
vincristine 3 55.00 Quite High
Kinase C 16 20.08 Low Low
chemokine 40 5.00 Very Low Very Low Very Low
cINOD 20 5.00 Very Low Very Low Very Low
Arthritis 20 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 589 99.66 Very High Very High Very High
Hepatocellular Cancer 8 96.56 Very High Very High Very High
INFLAMMATION 480 93.40 High High
Lymphatic System Cancer 86 91.08 High High
Glioma 8 85.96 High High
Breast Cancer 20 77.52 Quite High
Mantle-cell Lymphoma 17 76.00 Quite High
Follicular Lymphoma 13 75.04 Quite High
Targeted Disruption 24 26.80 Quite Low
Chronic Disease 4 24.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A possible mechanism of TTP deficiency in tumor cell lines and tumors is silencing of TTP promoter due to epigenetic alterations as a result of changes in DNA methylation or altered chromatin [71].
Positive_regulation (due) of TTP associated with cancer
1) Confidence 0.07 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.05 Pain Relevance 0.10
Ectopic expression of HuR overcomes TTP-mediated destabilization of IL-3 mRNA and HuR mRNA in an ARE-dependent manner [69, 73].
Positive_regulation (overcomes) of TTP
2) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.39 Pain Relevance 0.16
Since the ERK pathway is overactivated in cancer, it is thought that ERK activation results in phosphorylation of TTP, leading to an increase in TTP mRNA targets such as VEGF [72].
Positive_regulation (increase) of TTP mRNA associated with cancer
3) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.91 Pain Relevance 0.05
The last group is heterogeneous and large and not necessarily functional while the key characteristic of other groupsÂ’ transcripts is the presence of the WWAUUUAUUUAWW sequence which likely RNA-binding proteins such as TTP could bind to, thus resulting in a large number of potential TTP and other RNA-binding protein mRNA targets [60].
Positive_regulation (resulting) of TTP
4) Confidence 0.05 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0 Pain Relevance 0
In the R-CHOP arm, median TTP was not reached after 3 years of observation.
Neg (not) Positive_regulation (reached) of TTP in arm
5) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727901 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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