INT27939

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Context Info
Confidence 0.27
First Reported 1989
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
epithelium 8
stroma 2
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 4 36.56 Quite Low
antagonist 3 15.04 Low Low
Kinase C 1 8.32 Low Low
agonist 44 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Incomplete Abortion 2 99.00 Very High Very High Very High
Spontaneous Abortion 5 96.04 Very High Very High Very High
Targeted Disruption 32 88.60 High High
Breast Cancer 11 57.60 Quite High
Frailty 3 39.64 Quite Low
Reprotox - General 1 3 37.20 Quite Low
Vomiting 1 32.48 Quite Low
Emergencies 1 25.00 Low Low
Hemorrhage 1 25.00 Low Low
Anxiety Disorder 4 20.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, since ER regulates synthesis of the progesterone receptor (PR), it is possible that antagonism of ER by tamoxifen results in PR downregulation and that PR may be involved in exocytosis of glycogen from the vaginal epithelium.
Positive_regulation (results) of Negative_regulation (downregulation) of PR in epithelium
1) Confidence 0.27 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.06 Pain Relevance 0
The elegant experiments performed by Kurita et al. on tissue cultures of stroma and epithelium from different combinations of wt and ERaKO suggest that E2 induced down-regulation of epithelial PR in the uterus is mediated through paracrine mechanisms mediated via ER?
Positive_regulation (mediated) of Negative_regulation (regulation) of epithelial PR in epithelium
2) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.24 Pain Relevance 0
The elegant experiments performed by Kurita et al. on tissue cultures of stroma and epithelium from different combinations of wt and ERaKO suggest that E2 induced down-regulation of epithelial PR in the uterus is mediated through paracrine mechanisms mediated via ER?
Positive_regulation (induced) of Negative_regulation (regulation) of epithelial PR in epithelium
3) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.25 Pain Relevance 0
As blockage of the progesterone receptor increases the myometrial sensitivity to prostaglandins, a combination of RU 486 and a prostaglandin E2-analogue was tested for termination of pregnancy.
Positive_regulation (increases) of Negative_regulation (blockage) of progesterone receptor associated with spontaneous abortion
4) Confidence 0.15 Published 1989 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 2694744 Disease Relevance 0.40 Pain Relevance 0
The elegant experiments performed by Kurita et al. on tissue cultures of stroma and epithelium from different combinations of wt and ERaKO suggest that E2 induced down-regulation of epithelial PR in the uterus is mediated through paracrine mechanisms mediated via ER?
Positive_regulation (induced) of in stroma Negative_regulation (regulation) of epithelial PR in epithelium
5) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.25 Pain Relevance 0
The elegant experiments performed by Kurita et al. on tissue cultures of stroma and epithelium from different combinations of wt and ERaKO suggest that E2 induced down-regulation of epithelial PR in the uterus is mediated through paracrine mechanisms mediated via ER?
Positive_regulation (mediated) of in stroma Negative_regulation (regulation) of epithelial PR in epithelium
6) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.24 Pain Relevance 0

General Comments

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