INT279394

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.67
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IK) nucleus (IK) cell-cell signaling (IK)
Anatomy Link Frequency
neurons 2
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 161 100.00 Very High Very High Very High
Neurotransmitter 2 95.12 Very High Very High Very High
Inflammation 88 88.12 High High
Inflammatory mediators 2 85.04 High High
chemokine 44 55.60 Quite High
antagonist 9 22.80 Low Low
fibrosis 3 18.08 Low Low
imagery 7 7.84 Low Low
metalloproteinase 204 5.00 Very Low Very Low Very Low
COX-2 inhibitor 46 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 92 100.00 Very High Very High Very High
Herpes Simplex Virus 476 99.98 Very High Very High Very High
Infection 209 99.98 Very High Very High Very High
INFLAMMATION 98 88.12 High High
Sarcoma 158 50.00 Quite Low
Malignant Neoplastic Disease 8 18.72 Low Low
Fibrosis 3 18.08 Low Low
Adhesions 84 5.00 Very Low Very Low Very Low
Cancer 42 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both conditions (upright–RED and upright–LED, Fig. 7B), differences in preferred directions of individual neurons were distributed both toward CCW and CW directions, and there was no significant difference in preferred directions between upright and RED on one hand (mean ?
Positive_regulation (upright) of Localization (upright) of RED in neurons
1) Confidence 0.09 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
Surprisingly, despite evidence of unregulated activation, Rab7 disease mutants have normal subcellular localization and associate normally with LAMP2 (Fig. 5B) and LysoTracker Red (data not shown).
Positive_regulation (activation) of Localization (localization) of Red associated with disease
2) Confidence 0.03 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.57 Pain Relevance 0
To evaluate the specificity of KSHV infection induced cytokine secretion, virus was pre-incubated with 100 µg of heparin/ml which has been shown to block about 80% of virus binding and entry into the various target cells [26],[35].
Positive_regulation (induced) of Localization (secretion) of cytokine associated with herpes simplex virus, infection and cytokine
3) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.97 Pain Relevance 0.42
Specificity of KSHV induced cytokine secretion
Positive_regulation (induced) of Localization (secretion) of cytokine associated with herpes simplex virus and cytokine
4) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.98 Pain Relevance 0.39
Excessive cytokine release within the transplantation site could lead to the production of other soluble factors by the MSCs themselves.
Positive_regulation (lead) of Localization (release) of cytokine associated with cytokine
5) Confidence 0.00 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727904 Disease Relevance 0.14 Pain Relevance 0.23

General Comments

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