INT279439

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C1s) extracellular region (C1s)
C1s (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 7 80.40 Quite High
ischemia 12 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
tissue acidosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Suicidal Behaviour 1 97.64 Very High Very High Very High
INFLAMMATION 9 80.40 Quite High
Death 15 71.32 Quite High
Breast Cancer 1 15.44 Low Low
Metastasis 1 13.28 Low Low
Myocardial Infarction 49 5.00 Very Low Very Low Very Low
Paroxysmal Nocturnal Hemoglobinuria 27 5.00 Very Low Very Low Very Low
Glomerulonephritis 23 5.00 Very Low Very Low Very Low
Coronary Artery Disease 16 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the classical pathway, one of the main complement regulatory proteins is C1 inhibitor (C1-INH), which binds to the C1r:C1s complex and causes it to dissociate from C1q, thus preventing activation of the complement system.
C1s Binding (complex) of
1) Confidence 0.11 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.29 Pain Relevance 0.11
These serine protease inhibitors interact with the active sites of their target serine proteases as suicide substrates by the formation of covalent enzyme-inhibitor complexes, which results in enzymatically inactive proteases.
serine protease Binding (interact) of associated with suicidal behaviour
2) Confidence 0.05 Published 2010 Journal J Mol Histol Section Body Doc Link PMC2852590 Disease Relevance 0.10 Pain Relevance 0

General Comments

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