INT279443

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd59a)
Anatomy Link Frequency
erythrocytes 1
Cd59a (Mus musculus)
Pain Link Frequency Relevance Heat
cva 8 90.68 High High
Inflammation 7 49.52 Quite Low
abdominal pain 1 24.20 Low Low
ischemia 12 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
tissue acidosis 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Paroxysmal Nocturnal Hemoglobinuria 27 99.08 Very High Very High Very High
Hemolysis 5 96.96 Very High Very High Very High
Cv General 3 Under Development 8 90.68 High High
Glomerulonephritis 23 57.44 Quite High
INFLAMMATION 9 49.52 Quite Low
Proteinuria 5 40.96 Quite Low
Hematuria 3 39.92 Quite Low
Renal Disease 8 33.52 Quite Low
Reprotox - General 2 1 25.68 Quite Low
Dysphagia 1 24.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies with human PNH erythrocytes showed that recombinant soluble CD59 was able to bind to the surface of RBCs at levels sufficient to inhibit complement-mediated hemolysis (Hill et al 2006).
CD59 Binding (bind) of in erythrocytes associated with hemolysis and paroxysmal nocturnal hemoglobinuria
1) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0.92 Pain Relevance 0.17

General Comments

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