INT279459

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.76
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd59a)
Anatomy Link Frequency
brain 2
Cd59a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 108 99.64 Very High Very High Very High
cva 16 95.80 Very High Very High Very High
Inflammation 41 85.04 High High
cytokine 9 84.96 Quite High
Inflammatory response 13 78.56 Quite High
rheumatoid arthritis 2 51.00 Quite High
chemokine 3 33.44 Quite Low
isoflurane 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Paroxysmal Nocturnal Hemoglobinuria 57 99.72 Very High Very High Very High
Cv Unclassified Under Development 49 99.64 Very High Very High Very High
Middle Cerebral Artery Infarction 126 98.36 Very High Very High Very High
Myocardial Infarction 98 98.04 Very High Very High Very High
Stroke 69 97.60 Very High Very High Very High
Cv General 3 Under Development 16 95.80 Very High Very High Very High
Acute Coronary Syndrome 6 94.16 High High
Atherosclerotic Plaque 8 92.24 High High
Apoptosis 18 89.56 High High
Coronary Artery Disease 32 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was recently shown that ischemia leads to a rapid loss of membranous CD59 protein in the ischemic core region [41,6].
Negative_regulation (loss) of CD59 associated with ischemia
1) Confidence 0.58 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 1.01 Pain Relevance 0.14
This study demonstrates that deficiency of the complement regulator protein CD59a exacerbates post-ischemic brain damage in vivo in a gender-specific way and depending on the severity of the stroke.
Negative_regulation (deficiency) of CD59a in brain associated with stroke
2) Confidence 0.43 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.81 Pain Relevance 0.15
CD59 deficiency has no influence on CD11b-positive cell accumulation in post-ischemic brain tissue
Negative_regulation (deficiency) of CD59 in brain
3) Confidence 0.43 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.82 Pain Relevance 0.08
Interestingly, the presence of C5b-9 in necrotic tissue was associated with the loss of CD59 in postmortem studies on patients who died from MI (Väkevä et al 1992).
Negative_regulation (loss) of CD59 associated with myocardial infarction
4) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.52 Pain Relevance 0.11
DAF and CD59, complement regulatory proteins, are two GPI-anchored molecules; therefore, PNH cells have a deficiency of DAF and/or CD59 on their cell membrane and are more susceptible to destruction by complement.
Negative_regulation (deficiency) of CD59 associated with paroxysmal nocturnal hemoglobinuria
5) Confidence 0.15 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 1.61 Pain Relevance 0.03

General Comments

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