INT279534

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTPN11) extracellular space (CFH) extracellular region (CFH)
cytoplasm (PTPN11)
CFH (Homo sapiens)
PTPN11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue 208 98.52 Very High Very High Very High
Disease 34 96.84 Very High Very High Very High
Flavivirus Infection 160 95.16 Very High Very High Very High
Infection 76 88.96 High High
Hemolytic Uremic Syndrome 2 84.64 Quite High
Age-related Macular Degeneration 2 83.08 Quite High
Increased Venous Pressure Under Development 2 80.96 Quite High
Convalescence 8 58.80 Quite High
Dengue Hemorrhagic Fever 2 22.32 Low Low
Pressure Volume 2 Under Development 2 21.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the NS1 protein of West Nile virus, another flavivirus which does not normally induce vasculopathy, has been shown to bind to complement regulatory factor H [15] and use this mechanism as an immune evasion mechanism.
factor H Binding (bind) of NS1
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.16 Pain Relevance 0
Interestingly, studies on NS1 protein from West Nile virus have shown that this protein can bind to factor H, recruiting this complement protein to the surface of infected cells, allowing NS1 bound cells to escape from complement-mediated lyses [15].
factor H Binding (bind) of NS1
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.38 Pain Relevance 0

General Comments

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