INT27954

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2011
Negated 0
Speculated 8
Reported most in Abstract
Documents 87
Total Number 95
Disease Relevance 57.91
Pain Relevance 51.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
nerve 44
skin 16
sensory neurons 10
spinal cord 8
lung 6
Ngf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 817 100.00 Very High Very High Very High
Inflammation 580 100.00 Very High Very High Very High
Pain 243 100.00 Very High Very High Very High
cytokine 139 100.00 Very High Very High Very High
Calcitonin gene-related peptide 84 100.00 Very High Very High Very High
nociceptor 66 100.00 Very High Very High Very High
Hyperalgesia 63 100.00 Very High Very High Very High
sodium channel 26 100.00 Very High Very High Very High
Neuropeptide 148 99.92 Very High Very High Very High
dorsal root ganglion 76 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 602 100.00 Very High Very High Very High
Pain 209 100.00 Very High Very High Very High
Targeted Disruption 169 100.00 Very High Very High Very High
Cancer 116 100.00 Very High Very High Very High
Hyperalgesia 97 100.00 Very High Very High Very High
Melanoma 51 100.00 Very High Very High Very High
Necrosis 30 100.00 Very High Very High Very High
Nociception 93 99.92 Very High Very High Very High
Cystitis 59 99.90 Very High Very High Very High
Pancreatic Cancer 1 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of nerve growth factor in nerve associated with targeted disruption, qutenza and nerve growth factor
1) Confidence 0.70 Published 1998 Journal Am. J. Respir. Cell Mol. Biol. Section Title Doc Link 9476901 Disease Relevance 0.64 Pain Relevance 0.70
Two lineages of CCSP-NGF transgenic mice overexpressed NGF in the lung and developed a hyperinnervation of the airways.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of NGF in lung associated with targeted disruption and nerve growth factor
2) Confidence 0.70 Published 1998 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 9476901 Disease Relevance 0.59 Pain Relevance 0.65
We conclude that NGF overexpression from a lung-specific promoter produces anatomic and functional changes in lung innervation, and that CCSP-NGF mice will be useful for studying the role of neurogenic inflammation in airway disease.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NGF in lung associated with inflammation, nerve growth factor, disease and neurogenic inflammation
3) Confidence 0.70 Published 1998 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 9476901 Disease Relevance 0.49 Pain Relevance 0.68
Overexpression of nerve growth factor in skin selectively affects the survival and functional properties of nociceptors.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of nerve growth factor in skin associated with nerve growth factor and nociceptor
4) Confidence 0.70 Published 1999 Journal J. Neurosci. Section Title Doc Link 10493751 Disease Relevance 0.09 Pain Relevance 0.78
Mice that overexpress nerve growth factor (NGF-OE) in the skin have double the normal number of cutaneous sensory neurons, have increased innervation of the skin and spinal cord, and are hyperalgesic.
Positive_regulation (overexpress) of Gene_expression (overexpress) of nerve growth factor in spinal cord associated with hyperalgesia, nerve growth factor and spinal cord
5) Confidence 0.70 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10493751 Disease Relevance 0.09 Pain Relevance 0.31
However, reverse transcriptase polymerase chain reaction analysis showed no apparent expression of transgene mRNA in sensory ganglia, suggesting that the additional NGF was derived from increased NGF expression in the skin.
Positive_regulation (increased) of Gene_expression (expression) of NGF in skin associated with nerve growth factor
6) Confidence 0.70 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7852636 Disease Relevance 0.78 Pain Relevance 0.59
The present study demonstrates that novel sympathetic projections to sensory neurons are also induced in transgenic mice that overexpress nerve growth factor (NGF) in the skin.
Positive_regulation (overexpress) of Gene_expression (overexpress) of NGF in nerve associated with targeted disruption and nerve growth factor
7) Confidence 0.70 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7852636 Disease Relevance 0.88 Pain Relevance 0.35
Overexpression of nerve growth factor in transgenic mice induces novel sympathetic projections to primary sensory neurons.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of nerve growth factor in sympathetic associated with targeted disruption and nerve growth factor
8) Confidence 0.70 Published 1994 Journal J. Comp. Neurol. Section Title Doc Link 7852636 Disease Relevance 0.84 Pain Relevance 0.35
These results indicate that NGF can induce novel sympathetic projections to sensory neurons in vivo and suggests a model in which increased NGF expression plays a role in the development of sympathetic hyperalgesia after nerve injury.
Positive_regulation (increased) of Gene_expression (expression) of NGF in sensory neurons associated with hyperalgesia, nervous system injury and nerve growth factor
9) Confidence 0.70 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7852636 Disease Relevance 0.81 Pain Relevance 0.53
Glial overexpression of NGF enhances neuropathic pain and adrenergic sprouting into DRG following chronic sciatic constriction in mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NGF associated with pain and neuropathic pain
10) Confidence 0.70 Published 1998 Journal Neurosci. Lett. Section Title Doc Link 9714463 Disease Relevance 0.51 Pain Relevance 0.79
These results demonstrate a connection between the endogenous ectopic overexpression of NGF and (1) neuropathic pain behaviour and (2) sympathetic sprouting in the DRG.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NGF in DRG associated with nerve growth factor and neuropathic pain
11) Confidence 0.70 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9714463 Disease Relevance 0.57 Pain Relevance 0.70
We investigated effects of chronic constriction injury (CCI) on behavior and sprouting in mice in which NGF overexpression is driven by a glial protein (GFAP) promotor.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NGF associated with nerve growth factor, eae and injury
12) Confidence 0.70 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9714463 Disease Relevance 0.53 Pain Relevance 0.69
Transgenic mice constitutively overexpressing NGF in the airways (Clara-cell secretory protein promoter [CCSP]-NGF-tg) were employed and compared with wild-type animals.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of NGF associated with targeted disruption and nerve growth factor
13) Confidence 0.70 Published 2002 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 12231491 Disease Relevance 0.94 Pain Relevance 0.72
These results indicate that DADLE is one of the most potent agents in increasing the NGF in the biological system and that this action of DADLE involves selective increases of c-Jun and c-Fos, transcription factors that promote the NGF expression.
Positive_regulation (promote) of Gene_expression (expression) of NGF associated with nerve growth factor
14) Confidence 0.70 Published 2005 Journal Synapse Section Abstract Doc Link 15945062 Disease Relevance 0 Pain Relevance 0.61
We examined whether inflammation or transient overexpression of nerve growth factor (NGF) in one tissue triggers hypersensitivity in referral sites.
Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of NGF in nerve associated with nerve growth factor, inflammation and hypersensitivity
15) Confidence 0.70 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16500917 Disease Relevance 0.62 Pain Relevance 0.34
We also examined mice in which nerve growth factor (NGF) is overexpressed in the skin.
Spec (examined) Positive_regulation (overexpressed) of Gene_expression (overexpressed) of nerve growth factor in skin associated with nerve growth factor
16) Confidence 0.70 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10712492 Disease Relevance 0.28 Pain Relevance 0.46
The aim of this study was to investigate the in vivo effects of CNS over-expression of nerve growth factor (NGF) on primary sensory neurons.
Spec (investigate) Positive_regulation (over) of Gene_expression (over) of NGF in primary sensory neurons associated with nerve growth factor
17) Confidence 0.69 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 8542060 Disease Relevance 0.30 Pain Relevance 0.65
The aim of this study was to investigate the in vivo effects of CNS over-expression of nerve growth factor (NGF) on primary sensory neurons.
Spec (investigate) Positive_regulation (over) of Gene_expression (expression) of nerve growth factor in primary sensory neurons associated with nerve growth factor
18) Confidence 0.69 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 8542060 Disease Relevance 0.30 Pain Relevance 0.62
Nerve growth factor expression in the hind paw skin was also increased in a variety of dermal cell types and nerve fibers, suggesting the contribution of a peripheral source of NGF to mechanical allodynia.
Positive_regulation (increased) of Gene_expression (expression) of Nerve growth factor in nerve associated with allodynia and nerve growth factor
19) Confidence 0.69 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19816194 Disease Relevance 1.39 Pain Relevance 1.35
Overexpression of NGF or GDNF alters transcriptional plasticity evoked by inflammation.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of NGF associated with inflammation
20) Confidence 0.69 Published 2005 Journal Pain Section Title Doc Link 15661434 Disease Relevance 1.07 Pain Relevance 0.66

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