INT27955

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 10.43
Pain Relevance 10.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
nerve 4
joint 2
cardiac myocyte 2
cerebrospinal fluid 2
sympathetic 2
Ngf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 235 100.00 Very High Very High Very High
Inflammation 104 100.00 Very High Very High Very High
substance P 30 99.92 Very High Very High Very High
Hyperalgesia 18 99.92 Very High Very High Very High
cytokine 47 99.80 Very High Very High Very High
Antihistamine 4 99.60 Very High Very High Very High
ketamine 3 99.60 Very High Very High Very High
Pain 83 99.38 Very High Very High Very High
Enkephalin 1 99.28 Very High Very High Very High
Trk A 12 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 114 100.00 Very High Very High Very High
Hypersensitivity 18 100.00 Very High Very High Very High
Hyperalgesia 20 99.92 Very High Very High Very High
Leishmaniasis 7 99.92 Very High Very High Very High
Pancreatic Cancer 1 99.78 Very High Very High Very High
Pain 73 99.38 Very High Very High Very High
Cystitis 2 99.32 Very High Very High Very High
Eczema 216 99.08 Very High Very High Very High
Interstitial Cystitis 1 98.80 Very High Very High Very High
Contact Dermatitis 2 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of NGF in the post-operative phase of pain was TNF-dependent as anti-TNF reduced NGF expression in the joint and abrogated pain.
Negative_regulation (reduced) of Gene_expression (expression) of NGF in joint associated with pain and nerve growth factor
1) Confidence 0.59 Published 2010 Journal Pain Section Abstract Doc Link 20350782 Disease Relevance 1.55 Pain Relevance 1.95
2 agonists or inhaled steroids, both of which are known to suppress NGF production (Amann and Schuligoi 2004; Noga et al. 2001).
Negative_regulation (suppress) of Gene_expression (production) of NGF associated with nerve growth factor and agonist
2) Confidence 0.58 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257644 Disease Relevance 0.06 Pain Relevance 0.54
Conversely, local injection of low doses of recombinant LIF diminishes mechanical and thermal hypersensitivity as well as the IL-1beta and NGF expression induced by CFA.
Negative_regulation (diminishes) of Gene_expression (expression) of NGF associated with nerve growth factor and hypersensitivity
3) Confidence 0.57 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651226 Disease Relevance 0.68 Pain Relevance 0.60
Modulating bladder neuro-inflammation: RDP58, a novel anti-inflammatory peptide, decreases inflammation and nerve growth factor production in experimental cystitis.
Negative_regulation (decreases) of Gene_expression (production) of nerve growth factor in nerve associated with nerve growth factor, inflammation and cystitis
4) Confidence 0.52 Published 2005 Journal J. Urol. Section Title Doc Link 15643278 Disease Relevance 0.69 Pain Relevance 0.52
We conclude that thymulin can modulate the hyperalgesia induced by CL by decreasing the levels of the proinflammatory factors IL-1beta and NGF.
Negative_regulation (decreasing) of Gene_expression (levels) of NGF associated with leishmaniasis, hyperalgesia and nerve growth factor
5) Confidence 0.43 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 1.04 Pain Relevance 0.77
Animal studies have since shown that site-specific viral-mediated expression of NGF in the lumbar dorsal root ganglia prevents peripheral nerve dysfunction associated with chemically induced neuropathy.
Negative_regulation (prevents) of Gene_expression (expression) of NGF in peripheral nerve associated with nerve growth factor, induced neuropathy and neuropathic pain
6) Confidence 0.43 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16427624 Disease Relevance 0.72 Pain Relevance 0.55
For example, Zhu et al found that human pancreatic cancers with high levels of NGF expression demonstrated more extensive perineureal invasion, and more severe and refractory pain [18].
Negative_regulation (levels) of Gene_expression (expression) of NGF associated with pain refractory, nerve growth factor and pancreatic cancer
7) Confidence 0.41 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2291052 Disease Relevance 1.54 Pain Relevance 0.90
These data suggest that IL-10 inhibits ET-induced hyperalgesia by downregulation of TNFalpha, IL-1beta and NGF production.
Negative_regulation (downregulation) of Gene_expression (production) of NGF associated with hyperalgesia
8) Confidence 0.41 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9663559 Disease Relevance 0.50 Pain Relevance 0.29
Moreover, in studies of BALB/c mice with chronic contact hypersensitivity induced by oxazolone, it has been reported that oral administration of olopatadine suppressed the production of NGF and cytokines such as IL-4, IL-1?
Negative_regulation (suppressed) of Gene_expression (production) of NGF associated with nerve growth factor, contact dermatitis and cytokine
9) Confidence 0.39 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.50 Pain Relevance 0.88
, IL-6 and GM-CSF in the affected ear tissues, unlike other histamine H1 receptor antagonists.29-31 From these results, olopatadine is suggested to exerts its effect on AD not only by antihistamine effect but also by suppressing the production of NGF and SP.
Negative_regulation (suppressing) of Gene_expression (production) of NGF in ear associated with nerve growth factor, antihistamine, antagonist, eczema and substance p
10) Confidence 0.39 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.75 Pain Relevance 0.84
Previously, we reported enhanced NGF expression and phosphorylation of Trk A receptors in LDRG of db/db mice during the period of mechanical allodynia.
Negative_regulation (reported) of Gene_expression (expression) of NGF associated with allodynia, nerve growth factor and trk a
11) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.37 Pain Relevance 0.75
We also evaluated the levels of nerve growth factor, substance P and enkephalins in the cerebrospinal fluid of these patients.
Negative_regulation (evaluated) of Gene_expression (levels) of nerve growth factor in cerebrospinal fluid associated with nerve growth factor, enkephalin and substance p
12) Confidence 0.36 Published 2010 Journal Eur J Cancer Care (Engl) Section Abstract Doc Link 19490010 Disease Relevance 1.22 Pain Relevance 0.77
Moreover, Cot/tpl2 deficiency dramatically decreased the production of the hypernociceptive ligand NGF at the inflammatory site during the course of inflammation.
Negative_regulation (decreased) of Gene_expression (production) of NGF associated with inflammation
13) Confidence 0.28 Published 2010 Journal J. Biol. Chem. Section Abstract Doc Link 20736176 Disease Relevance 0.68 Pain Relevance 0.50
Moreover, there is evidence of feedback inhibition of cardiac myocyte production of NGF at high levels of norepinephrine.
Negative_regulation (inhibition) of Gene_expression (production) of NGF in cardiac myocyte
14) Confidence 0.27 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.07 Pain Relevance 0
High sympathetic tone in an innervated organ presumably inhibits its NGF production.
Negative_regulation (inhibits) of Gene_expression (production) of NGF in sympathetic
15) Confidence 0.27 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.06 Pain Relevance 0
MAPK ERK1/2 pathway inhibitors blunted IL-6 production following NGF or BDNF exposure
Negative_regulation (blunted) of Gene_expression (production) of NGF
16) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0
The activation of receptors coupled to adenylate cyclase elicited the increase of proenkephalin and nerve growth factor gene expression.
Negative_regulation (elicited) of Gene_expression (expression) of nerve growth factor in nerve associated with nerve growth factor
17) Confidence 0.02 Published 1989 Journal Pharmacol. Res. Section Abstract Doc Link 2698474 Disease Relevance 0 Pain Relevance 0.30

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