INT279572

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 30
Disease Relevance 20.88
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MBL2) extracellular region (MBL2)
Anatomy Link Frequency
plasma 2
platelet 1
MBL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 232 98.92 Very High Very High Very High
Inflammation 124 97.84 Very High Very High Very High
rheumatoid arthritis 55 97.60 Very High Very High Very High
cytokine 29 95.16 Very High Very High Very High
Chronic pancreatitis 7 77.92 Quite High
chemokine 13 73.16 Quite High
Potency 18 57.28 Quite High
metalloproteinase 7 40.00 Quite Low
antagonist 4 39.80 Quite Low
palliative 7 39.12 Quite Low
Disease Link Frequency Relevance Heat
Cancer 264 99.92 Very High Very High Very High
Dengue 416 99.16 Very High Very High Very High
Pancreatic Cancer 343 99.00 Very High Very High Very High
Dyspepsia 232 98.92 Very High Very High Very High
Flavivirus Infection 320 98.76 Very High Very High Very High
Gastritis 16 98.76 Very High Very High Very High
Syndrome 89 98.64 Very High Very High Very High
Acute-phase Reaction 7 98.12 Very High Very High Very High
INFLAMMATION 113 97.84 Very High Very High Very High
Disease 294 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are three functional single nucleotide polymorphisms within exon 1 of the MBL2 gene which lead to low serum MBL levels.
Gene_expression (levels) of MBL2
1) Confidence 0.64 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.21 Pain Relevance 0
Genotype analysis revealed specific point mutations in the MBL2 promoter in all 6 patients and a variant MASP-2 gene in one patient.
Gene_expression (promoter) of MBL2
2) Confidence 0.64 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2856528 Disease Relevance 1.27 Pain Relevance 0.08
Further validation studies in an independent set of serum samples from 16 pancreatic cancer patients and 16 non-cancer-bearing controls demonstrated increased levels of MBL2 and MLCK2.
Gene_expression (levels) of MBL2 associated with cancer and pancreatic cancer
3) Confidence 0.58 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.92 Pain Relevance 0
We further confirmed the expression levels of two up-regulated proteins (MBL2 and MLCK2) in the sera from pancreatic cancer patients using western blot analysis.
Gene_expression (expression) of MBL2 associated with pancreatic cancer
4) Confidence 0.58 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 1.57 Pain Relevance 0.08
MBL-null mice incubated with intravenous S. aureus had a blunted production of TNF-?
Gene_expression (production) of MBL
5) Confidence 0.55 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.49 Pain Relevance 0.09
There are three functional single nucleotide polymorphisms within exon 1 of the MBL2 gene which lead to low serum MBL levels.
Gene_expression (levels) of MBL
6) Confidence 0.55 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.21 Pain Relevance 0
In order to identify the mechanism of the CP or LP activation we measured levels of C1q, CRP, CIC-C1q and oligomerized MBL in plasma samples from DF and DHF patients (Figure 4; Table 2).
Gene_expression (levels) of MBL in plasma associated with flavivirus infection and dengue
7) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.61 Pain Relevance 0
In our study, we showed for the first time that the serum levels of MBL2 were significantly higher in pancreatic cancer patients than in the non-cancer-bearing controls (Figure 4A), suggesting that MBL2 might represent a new serum marker for pancreatic cancer.
Gene_expression (levels) of MBL2 associated with cancer and pancreatic cancer
8) Confidence 0.50 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 1.23 Pain Relevance 0
Anti-MBL2, anti-MLCK2 and anti-?
Gene_expression (Anti) of MBL2
9) Confidence 0.50 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.26 Pain Relevance 0
Anti-MBL2, anti-MLCK2 and anti-?
Gene_expression (anti) of MBL2
10) Confidence 0.50 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.26 Pain Relevance 0
Defective MBL production is regarded as the most common immune deficiency in the general population, affecting approximately 5-7% of individuals [2], although some descriptions have delineated higher figures among Caucasians (up to 30%) [3].
Gene_expression (production) of MBL
11) Confidence 0.50 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.41 Pain Relevance 0.21
Plasma levels of complement factor D, anaphylotoxins, MBL oligomers, and total IgG immunocomplexes (CIC-C1q) were measured using the Duo Set ELISA development kit for human factor D (R&D systems), the Cytometric Bead Array kit for human anaphylotoxin (BD Biosciences), the MBL oligomer ELISA kit (Innate Immunity Diagnostics), and the CIC-C1q ELISA kit (Quidel), respectively, according to manufacturer directions.
Gene_expression (levels) of MBL in Plasma
12) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.08 Pain Relevance 0
Factor H was also highly correlated with platelet levels in the dengue patients, whereas C1q, CIC-C1q, CRP, and MBL protein levels were not (Table 3).
Gene_expression (levels) of MBL in platelet associated with dengue
13) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.49 Pain Relevance 0
However, small but statistically significant differences were detected in the levels of MBL.
Gene_expression (detected) of MBL
14) Confidence 0.47 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2728508 Disease Relevance 1.25 Pain Relevance 0
MBL2, which was found in this study to be increased in pancreatic cancer serum, has not been identified previously as a marker of pancreatic cancer.
Gene_expression (found) of MBL2 associated with pancreatic cancer
15) Confidence 0.45 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.72 Pain Relevance 0
Western blots showed the consistent over-expressed of MBL2 and MLCK2 in individual pancreatic cancer patients compared with individual non-cancer-bearing donors (n = 16), and the Figure 3 showed the western blot results of 16 pairs of the pancreatic cancer sera and non-cancer-bearing controls' sera.
Gene_expression (expressed) of MBL2 associated with cancer and pancreatic cancer
16) Confidence 0.45 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.82 Pain Relevance 0
It was reported that mucosal expression of MBL was up-regulated in H. pylori gastritis [26].
Gene_expression (expression) of MBL associated with gastritis
17) Confidence 0.32 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 0.58 Pain Relevance 0.10
TLR2 and MBL genotypes
Gene_expression (genotypes) of MBL
18) Confidence 0.27 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 1.12 Pain Relevance 0.29
In over all subjects, no significant differences were found between both TLR2 and MBL2 genotypes frequencies and FD.
Neg (no) Gene_expression (found) of MBL2 associated with nud
19) Confidence 0.27 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 1.17 Pain Relevance 0.38
Genotyping for TLR2 and MBL genes
Gene_expression (genes) of MBL
20) Confidence 0.27 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 0.42 Pain Relevance 0

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