INT279576

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MBL2) extracellular region (MBL2)
MBL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 40.40 Quite Low
palliative 2 31.92 Quite Low
Potency 2 7.36 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 98 99.60 Very High Very High Very High
Cancer 75 99.38 Very High Very High Very High
Flavivirus Infection 80 98.64 Very High Very High Very High
Dengue 104 97.36 Very High Very High Very High
Hereditary Angioedema 41 96.16 Very High Very High Very High
Infection 70 95.84 Very High Very High Very High
Disease 56 81.80 Quite High
Dermatological Disease 9 75.80 Quite High
Autoimmune Disease 5 71.76 Quite High
Convalescence 4 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon binding to PAMPs, the MBL pathway and MASP recruitment are activated.
Positive_regulation (activated) of MBL
1) Confidence 0.38 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.41 Pain Relevance 0
Further validation studies in an independent set of serum samples from 16 pancreatic cancer patients and 16 non-cancer-bearing controls demonstrated increased levels of MBL2 and MLCK2.
Positive_regulation (increased) of MBL2 associated with cancer and pancreatic cancer
2) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.92 Pain Relevance 0
Up-regulation of serum MBL2 and MLCK2 in pancreatic cancer was found by the DIGE and the 3 D spot images were shown in Figure 2.
Positive_regulation (regulation) of MBL2 associated with pancreatic cancer
3) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.65 Pain Relevance 0
The activity of the LP was evaluated by measuring the levels of oligomerized MBL, and a significant increase of MBL oligomerization was found in the DHF patients as compared to the DF patients during the acute phase of infection, which might have contributed to the elevated C4a level.
Positive_regulation (increase) of MBL associated with flavivirus infection, dengue and infection
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.48 Pain Relevance 0
Activation of the MBL pathway might therefore be an additional element which could worsen the status of persons with HAE and/or, due to C1-INH consumption, contribute to triggering attacks.
Positive_regulation (Activation) of MBL associated with hereditary angioedema
5) Confidence 0.09 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.64 Pain Relevance 0

General Comments

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